Research ArticleInflammation

Familial autoinflammation with neutrophilic dermatosis reveals a regulatory mechanism of pyrin activation

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Science Translational Medicine  30 Mar 2016:
Vol. 8, Issue 332, pp. 332ra45
DOI: 10.1126/scitranslmed.aaf1471

Article Information

vol. 8 no. 332 332ra45

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History: 
  • Received for publication December 23, 2015
  • Accepted for publication March 3, 2016
  • .

Author Information

  1. Seth L. Masters1,2,*,
  2. Vasiliki Lagou3,4,5,,
  3. Isabelle Jéru6,7,8,,
  4. Paul J. Baker1,2,,
  5. Lien Van Eyck4,5,
  6. David A. Parry9,
  7. Dylan Lawless10,
  8. Dominic De Nardo1,2,
  9. Josselyn E. Garcia-Perez4,5,
  10. Laura F. Dagley1,2,11,
  11. Caroline L. Holley12,
  12. James Dooley4,5,
  13. Fiona Moghaddas1,2,
  14. Emanuela Pasciuto4,5,
  15. Pierre-Yves Jeandel13,
  16. Raf Sciot14,15,
  17. Dena Lyras16,
  18. Andrew I. Webb2,11,
  19. Sandra E. Nicholson1,2,
  20. Lien De Somer15,
  21. Erika van Nieuwenhove4,5,15,
  22. Julia Ruuth-Praz7,8,
  23. Bruno Copin8,
  24. Emmanuelle Cochet8,
  25. Myrna Medlej-Hashim17,
  26. Andre Megarbane18,
  27. Kate Schroder12,
  28. Sinisa Savic19,20,
  29. An Goris3,
  30. Serge Amselem6,7,8,
  31. Carine Wouters4,15,*, and
  32. Adrian Liston4,5,*,
  1. 1Inflammation Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, 3052, Australia.
  2. 2Department of Medical Biology, The University of Melbourne, Parkville, Victoria 3010, Australia.
  3. 3Department of Neurosciences, KU Leuven, Leuven 3000, Belgium.
  4. 4Department of Microbiology and Immunology, KU Leuven, Leuven 3000, Belgium.
  5. 5Translational Immunology Laboratory, VIB, Leuven 3000, Belgium.
  6. 6INSERM, UMR S933, Paris F-75012, France.
  7. 7Université Pierre et Marie Curie–Paris, UMR S933, Paris F-75012, France.
  8. 8Assistance Publique Hôpitaux de Paris, Hôpital Trousseau, Service de Génétique et d’Embryologie médicales, Paris F-75012, France.
  9. 9Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Crewe Road South, Edinburgh LS7 4SA, UK.
  10. 10Leeds Institute of Biomedical and Clinical Sciences, University of Leeds, Wellcome Trust Brenner Building, Saint James’s University Hospital, Leeds LS7 4SA, UK.
  11. 11Systems Biology and Personalised Medicine Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia.
  12. 12Institute for Molecular Bioscience (IMB) and IMB Centre for Inflammation and Disease Research, The University of Queensland, Brisbane, Queensland 4072, Australia.
  13. 13Département de Médecine Interne, Hôpital Archet 1, Université Nice Sophia-Antipolis, 06202 Nice, France.
  14. 14Department of Pathology, KU Leuven, Leuven 3000, Belgium.
  15. 15University Hospitals Leuven, Leuven 3000, Belgium.
  16. 16Department of Microbiology, Monash University, Melbourne, Victoria 3800, Australia.
  17. 17Department of Life and Earth Sciences, Faculty of Sciences II, Lebanese University, Beirut 1102 2801, Lebanon.
  18. 18Al-Jawhara Center, Arabian Gulf University, Manama 26671, Bahrain.
  19. 19Department of Allergy and Clinical Immunology, Saint James’s University Hospital, Leeds LS9 7TF, UK.
  20. 20National Institute for Health Research–Leeds Musculoskeletal Biomedical Research Unit and Leeds Institute of Rheumatic and Musculoskeletal Medicine, Wellcome Trust Brenner Building, Saint James’s University Hospital, Beckett Street, Leeds LS9 7TF, UK.
  1. *Corresponding author. E-mail: masters{at}wehi.edu.au (S.L.M.); carine.wouters{at}uzleuven.be (C.W.); adrian.liston{at}vib.be (A.L.)
    • These authors contributed equally as second authors.

    • These authors contributed equally as co-last authors.

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