Contents
30 March 2016
Vol 8, Issue 332
Vol 8, Issue 332
Contents
Research Articles
- Somatic PIK3CA mutations as a driver of sporadic venous malformations
PIK3CA mutations induce venous malformations.
- Somatic activating mutations in Pik3ca cause sporadic venous malformations in mice and humans
Mutant Pik3ca gives rise to venous malformations.
- Neuronal heparan sulfates promote amyloid pathology by modulating brain amyloid-β clearance and aggregation in Alzheimer’s disease
Deleting neuronal heparan sulfates in a mouse model of Alzheimer’s disease results in faster Aβ clearance, reduced Aβ aggregation, and less amyloid pathology.
- Familial autoinflammation with neutrophilic dermatosis reveals a regulatory mechanism of pyrin activation
A mutation in pyrin that disrupts regulation leads to autoinflammatory disease.
- Diversification of the antigen-specific T cell receptor repertoire after varicella zoster vaccination
Adult vaccination with an attenuated herpes zoster virus broadens the T cell receptor repertoire without reinforcing clonal dominance.
Editors' Choice
- Scientists flip-flop: Vitamin C suppresses immunity
The TET family of vitamin C–dependent enzymes stabilizes Foxp3 expression in regulatory T cells by demethylating conserved noncoding DNA.
- Intercepting reversible drug tolerance to improve targeted therapy
A repositioned HIV drug enhances the activity of targeted therapy by blocking reversible drug tolerance.
- Catch some T’s
Insomnia is associated with shorter telomere length in individuals 70 years old or older compared with individuals less than 70 years old.
About The Cover
ONLINE COVER PI3K the Best View. This cover depicts a Pik3ca-mutant mouse visualized by computerized tomography angiography, demonstrating a venous malformation seen as a green tumor on the left side of each image. In this issue, Castillo et al. and Castel et al. demonstrate that Pik3ca mutations can give rise to venous malformations and that they can be treated with pharmacological inhibitors of PI3Kα. [CREDIT: MAY ZAW-THIN, DANIEL J. STUCKEY, MARK F. LYTHGOE/CENTRE FOR ADVANCED BIOMEDICAL IMAGING, UNIVERSITY COLLEGE, LONDON]