30 March 2016
Vol 8, Issue 332

About The Cover

Cover image expansion

ONLINE COVER PI3K the Best View. This cover depicts a Pik3ca-mutant mouse visualized by computerized tomography angiography, demonstrating a venous malformation seen as a green tumor on the left side of each image. In this issue, Castillo et al. and Castel et al. demonstrate that Pik3ca mutations can give rise to venous malformations and that they can be treated with pharmacological inhibitors of PI3Kα. [CREDIT: MAY ZAW-THIN, DANIEL J. STUCKEY, MARK F. LYTHGOE/CENTRE FOR ADVANCED BIOMEDICAL IMAGING, UNIVERSITY COLLEGE, LONDON]