23 March 2016
Vol 8, Issue 331

About The Cover

Cover image expansion

ONLINE COVER Interfering with kidney injury. In this issue, Alidori and colleagues saddled carbon nanotubes (CNTs) with small interfering RNAs targeting two genes that play a role in kidney injury: p53 and meprin-1β. The functionalized CNTs naturally trafficked through mouse kidneys, delivering their RNA cargo and silencing the harmful pathways that are turned on in response to renal injury caused by toxic drugs; in this case, the common chemotherapeutic, cisplatin. The CNTs were also safe in monkeys. [CREDIT: C. BICKEL/SCIENCE TRANSLATIONAL MEDICINE]