Research ArticleBone

Chronic skin inflammation leads to bone loss by IL-17–mediated inhibition of Wnt signaling in osteoblasts

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Science Translational Medicine  16 Mar 2016:
Vol. 8, Issue 330, pp. 330ra37
DOI: 10.1126/scitranslmed.aad8996

Article Information

vol. 8 no. 330 330ra37

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication November 19, 2015
  • Accepted for publication February 2, 2016
  • .

Author Information

  1. Özge Uluçkan1,
  2. Maria Jimenez1,
  3. Susanne Karbach2,3,
  4. Anke Jeschke4,
  5. Osvaldo Graña5,
  6. Johannes Keller4,
  7. Björn Busse4,
  8. Andrew L. Croxford3,
  9. Stephanie Finzel6,
  10. Marije Koenders7,
  11. Wim van den Berg7,
  12. Thorsten Schinke4,
  13. Michael Amling4,
  14. Ari Waisman3,
  15. Georg Schett6 and
  16. Erwin F. Wagner1,*
  1. 1Cancer Cell Biology Program, Spanish National Cancer Research Centre (CNIO), 28029 Madrid, Spain.
  2. 2Center for Cardiology—Cardiology 1, University Medical Center, D-55131 Mainz, Germany.
  3. 3Institute of Molecular Medicine, University of Mainz, D-55131 Mainz, Germany.
  4. 4Department of Osteology and Biomechanics, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.
  5. 5Bioinformatics Unit, Biotechnology Department, Spanish National Cancer Research Center (CNIO), 28029 Madrid, Spain.
  6. 6Department of Internal Medicine 3, University of Erlangen-Nuremberg, 91054 Erlangen, Germany.
  7. 7Rheumatology Research and Advanced Therapeutics, Department of Rheumatology, Radboud University Nijmegen Medical Centre, 6525 Nijmegen, Netherlands.
  1. *Corresponding author. E-mail: ewagner{at}cnio.es

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