Research ArticleBone

Chronic skin inflammation leads to bone loss by IL-17–mediated inhibition of Wnt signaling in osteoblasts

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Science Translational Medicine  16 Mar 2016:
Vol. 8, Issue 330, pp. 330ra37
DOI: 10.1126/scitranslmed.aad8996

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IL-17 in skin and bones

Patients with psoriasis develop red, itchy, scaly patches on the skin in part because of the proinflammatory cytokine interleukin (IL)-17A. Now, Uluçkan et al. report that IL-17A may also lead to bone loss in affected individuals. They found in two different mouse models that in contrast to other types of inflammatory bone loss where osteoclast activation leads to bone degradation, IL-17A prevented new bone formation. Blocking IL-17A restored bone formation in vivo. If these data hold true in humans, targeting IL-17A in psoriasis may have the added benefit of blocking psoriasis-related bone loss.

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