Contents
16 March 2016
Vol 8, Issue 330
Vol 8, Issue 330
Contents
Editorial
- Once and future epidemics: Zika virus emerging
Zika virus again reminds us that we need a globally coordinated system to protect against outbreaks caused by perilous pathogens.
Focus
- Sclerostin: More than a bone formation brake
Anti-sclerostin spurs an unexpected acceleration of bone erosion in a mouse model of rheumatoid arthritis (Wehmeyer et al., this issue).
Research Articles
- Sclerostin inhibition promotes TNF-dependent inflammatory joint destruction
Blocking the Wnt inhibitor sclerostin leads to inflammatory joint destruction through enhanced activation of TNF receptor–mediated signaling, implicating sclerostin as protective in TNFα-dependent chronic inflammation.
- The live attenuated dengue vaccine TV003 elicits complete protection against dengue in a human challenge model
A controlled dengue human challenge model may determine whether to evaluate candidate dengue vaccines in large efficacy trials.
- Chronic skin inflammation leads to bone loss by IL-17–mediated inhibition of Wnt signaling in osteoblasts
Skin inflammation inhibits bone formation through IL-17A.
Reports
- Ipsilesional anodal tDCS enhances the functional benefits of rehabilitation in patients after stroke
Anodal tDCS applied to the ipsilesional motor cortex of patients with chronic stroke enhances the beneficial effects of motor rehabilitation.
Editors' Choice
- An old inhibitor with new tricks
Combination therapy offers new ways to enhance tumor immunotherapy.
- Diverse effects of statins in Alzheimer’s disease
Statins are linked to β-amyloid peptide through an astrocyte-mediated pathway.
- Barriers in food allergy prevention
“Thin-skinned” babies are more likely to develop food allergies 2 years later.
- Bad plumbing benefits nanoparticles
Tumor vasculature undergo vascular “bursts” that enable large particles to flow into the tumor interstitium.
About The Cover
ONLINE COVER Netting a Dengue Vaccine. Mosquito netting protects daytime sleepers from dengue virus transmission. Now Kirkpatrick et al. work to make this measure obsolete. They report on a human challenge model, which will aid in selecting dengue virus vaccines that can be moved into large-scale testing in endemic regions. [CREDIT: LIBA TAYLOR/CORBIS]