Research ArticleCancer

Development of a prosaposin-derived therapeutic cyclic peptide that targets ovarian cancer via the tumor microenvironment

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Science Translational Medicine  09 Mar 2016:
Vol. 8, Issue 329, pp. 329ra34
DOI: 10.1126/scitranslmed.aad5653

Article Information

vol. 8 no. 329 329ra34

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Print ISSN: 
Online ISSN: 
History: 
  • Received for publication October 1, 2015
  • Accepted for publication February 4, 2016
  • .

Author Information

  1. Suming Wang1,2,*,
  2. Anna Blois1,2,3,*,
  3. Tina El Rayes4,5,6,*,
  4. Joyce F. Liu7,8,
  5. Michelle S. Hirsch9,
  6. Karsten Gravdal3,10,
  7. Sangeetha Palakurthi11,
  8. Diane R. Bielenberg1,2,
  9. Lars A. Akslen3,10,
  10. Ronny Drapkin8,9,,
  11. Vivek Mittal4,5,6 and
  12. Randolph S. Watnick1,2,
  1. 1Vascular Biology Program, Boston Children’s Hospital, Boston, MA 02115, USA.
  2. 2Department of Surgery, Harvard Medical School, Boston, MA 02115, USA.
  3. 3Centre for Cancer Biomarkers (CCBIO), Department of Clinical Medicine, University of Bergen, NO-5020 Bergen, Norway.
  4. 4Department of Cardiothoracic Surgery, Weill Cornell Medical College, New York, NY 10065, USA.
  5. 5Department of Cell and Developmental Biology, Weill Cornell Medical College, New York, NY 10065, USA.
  6. 6Neuberger Berman Lung Cancer Center, Weill Cornell Medical College, New York, NY 10065, USA.
  7. 7Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.
  8. 8Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.
  9. 9Department of Pathology, Harvard Medical School, Boston, MA 02115, USA.
  10. 10Department of Pathology, Haukeland University Hospital, N-5021 Bergen, Norway.
  11. 11Belfer Center for Applied Cancer Science, Dana-Farber Cancer Institute, Boston, MA 02115, USA.
  1. Corresponding author. E-mail: randy.watnick{at}childrens.harvard.edu
  • * These authors contributed equally to this work.

  • Present address: Department of Obstetrics and Gynecology, Ovarian Cancer Research Center, University of Pennsylvania, Philadelphia, PA 19104, USA.

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