Two-mAb cocktail protects macaques against the Makona variant of Ebola virus

Xiangguo Qiu; Jonathan Audet; Ming Lv; Shihua He; Gary Wong; Haiyan Wei; Longlong Luo; Lisa Fernando; Andrea Kroeker; Hugues Fausther Bovendo; Alexander Bello; Feng Li; Pei Ye; Michael Jacobs; Giuseppe Ippolito; Erica Ollmann Saphire; Shengli Bi; Beifen Shen; George F. Gao; Larry Zeitlin; Jiannan Feng; Boyan Zhang; Gary P. Kobinger

doi:10.1126/scitranslmed.aad9875

Research ArticleInfectious Disease

Two-mAb cocktail protects macaques against the Makona variant of Ebola virus

Xiangguo Qiu¹,²,*,
Jonathan Audet¹,†,
Ming Lv³,†,
Shihua He¹,²,†,
Gary Wong²,‡,
Haiyan Wei²,⁴,
Longlong Luo³,
Lisa Fernando²,
Andrea Kroeker¹,²,
Hugues Fausther Bovendo²,
Alexander Bello²,
Feng Li⁵,
Pei Ye⁵,
Michael Jacobs⁶,
Giuseppe Ippolito⁷,
Erica Ollmann Saphire⁸,⁹,
Shengli Bi¹⁰,
Beifen Shen³,
George F. Gao¹¹,
Larry Zeitlin¹²,
Jiannan Feng³,*,
Boyan Zhang⁵,* and
Gary P. Kobinger¹,²,¹³,¹⁴,*

¹Department of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba R3E 0J9, Canada.
²National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba R3E 3R2, Canada.
³Laboratory of Immunology, Institute of Basic Medical Sciences, Taiping Road #27, Beijing 100850, China.
⁴Institute of Infectious Disease, Henan Center for Disease Control and Prevention, Zhengzhou, Henan 450012, China.
⁵Beijing Mabworks Biotech Co. Ltd., No. 99, Kechuang 14th Street, Economic-Technological Development Area, Beijing 101111, China.
⁶Royal Free London NHS (National Health Service) Foundation Trust, Pond Street, London NW3 2QG, UK.
⁷National Institute for Infectious Diseases “Lazzaro Spallanzani,” Rome 00149, Italy.
⁸Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA.
⁹Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.
¹⁰National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China.
¹¹CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, P.R. China.
¹²Mapp Biopharmaceutical Inc., San Diego, CA 92121, USA.
¹³Department of Immunology, University of Manitoba, Winnipeg, Manitoba R3E 0T5, Canada.
¹⁴Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104-4238, USA.

↵*Corresponding author. E-mail: xiangguo.qiu{at}phac-aspc.gc.ca (X.Q.); gary.kobinger{at}phac-aspc.gc.ca (G.P.K.); fengjiannan77{at}qq.com (J.F.); zhangby{at}mab-works.com (B.Z.)

↵† These authors contributed equally to this work.
↵‡ Present address: CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, P.R. China.

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Science Translational Medicine 09 Mar 2016:
Vol. 8, Issue 329, pp. 329ra33
DOI: 10.1126/scitranslmed.aad9875

Xiangguo Qiu

1Department of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba R3E 0J9, Canada.

2National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba R3E 3R2, Canada.

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For correspondence: xiangguo.qiu@phac-aspc.gc.ca gary.kobinger@phac-aspc.gc.ca fengjiannan77@qq.com zhangby@mab-works.com

Jonathan Audet

1Department of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba R3E 0J9, Canada.

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Ming Lv

3Laboratory of Immunology, Institute of Basic Medical Sciences, Taiping Road #27, Beijing 100850, China.

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Shihua He

1Department of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba R3E 0J9, Canada.

2National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba R3E 3R2, Canada.

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Gary Wong

2National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba R3E 3R2, Canada.

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Haiyan Wei

2National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba R3E 3R2, Canada.

4Institute of Infectious Disease, Henan Center for Disease Control and Prevention, Zhengzhou, Henan 450012, China.

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Longlong Luo

3Laboratory of Immunology, Institute of Basic Medical Sciences, Taiping Road #27, Beijing 100850, China.

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Lisa Fernando

2National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba R3E 3R2, Canada.

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Andrea Kroeker

1Department of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba R3E 0J9, Canada.

2National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba R3E 3R2, Canada.

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Hugues Fausther Bovendo

2National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba R3E 3R2, Canada.

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Alexander Bello

2National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba R3E 3R2, Canada.

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Feng Li

5Beijing Mabworks Biotech Co. Ltd., No. 99, Kechuang 14th Street, Economic-Technological Development Area, Beijing 101111, China.

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Pei Ye

5Beijing Mabworks Biotech Co. Ltd., No. 99, Kechuang 14th Street, Economic-Technological Development Area, Beijing 101111, China.

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Michael Jacobs

6Royal Free London NHS (National Health Service) Foundation Trust, Pond Street, London NW3 2QG, UK.

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Giuseppe Ippolito

7National Institute for Infectious Diseases “Lazzaro Spallanzani,” Rome 00149, Italy.

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Erica Ollmann Saphire

8Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA.

9Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.

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Shengli Bi

10National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China.

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Beifen Shen

3Laboratory of Immunology, Institute of Basic Medical Sciences, Taiping Road #27, Beijing 100850, China.

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George F. Gao

11CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, P.R. China.

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Larry Zeitlin

12Mapp Biopharmaceutical Inc., San Diego, CA 92121, USA.

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Jiannan Feng

3Laboratory of Immunology, Institute of Basic Medical Sciences, Taiping Road #27, Beijing 100850, China.

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For correspondence: xiangguo.qiu@phac-aspc.gc.ca gary.kobinger@phac-aspc.gc.ca fengjiannan77@qq.com zhangby@mab-works.com

Boyan Zhang

5Beijing Mabworks Biotech Co. Ltd., No. 99, Kechuang 14th Street, Economic-Technological Development Area, Beijing 101111, China.

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For correspondence: xiangguo.qiu@phac-aspc.gc.ca gary.kobinger@phac-aspc.gc.ca fengjiannan77@qq.com zhangby@mab-works.com

Gary P. Kobinger

1Department of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba R3E 0J9, Canada.

2National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba R3E 3R2, Canada.

13Department of Immunology, University of Manitoba, Winnipeg, Manitoba R3E 0T5, Canada.

14Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104-4238, USA.

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For correspondence: xiangguo.qiu@phac-aspc.gc.ca gary.kobinger@phac-aspc.gc.ca fengjiannan77@qq.com zhangby@mab-works.com

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Two-mAb cocktail protects macaques against the Makona variant of Ebola virus

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