Research ArticleInfectious Disease

Two-mAb cocktail protects macaques against the Makona variant of Ebola virus

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Science Translational Medicine  09 Mar 2016:
Vol. 8, Issue 329, pp. 329ra33
DOI: 10.1126/scitranslmed.aad9875

Article Information

vol. 8 no. 329 329ra33

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History: 
  • Received for publication December 2, 2015
  • Accepted for publication January 26, 2016
  • .

Author Information

  1. Xiangguo Qiu1,2,*,
  2. Jonathan Audet1,,
  3. Ming Lv3,,
  4. Shihua He1,2,,
  5. Gary Wong2,,
  6. Haiyan Wei2,4,
  7. Longlong Luo3,
  8. Lisa Fernando2,
  9. Andrea Kroeker1,2,
  10. Hugues Fausther Bovendo2,
  11. Alexander Bello2,
  12. Feng Li5,
  13. Pei Ye5,
  14. Michael Jacobs6,
  15. Giuseppe Ippolito7,
  16. Erica Ollmann Saphire8,9,
  17. Shengli Bi10,
  18. Beifen Shen3,
  19. George F. Gao11,
  20. Larry Zeitlin12,
  21. Jiannan Feng3,*,
  22. Boyan Zhang5,* and
  23. Gary P. Kobinger1,2,13,14,*
  1. 1Department of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba R3E 0J9, Canada.
  2. 2National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba R3E 3R2, Canada.
  3. 3Laboratory of Immunology, Institute of Basic Medical Sciences, Taiping Road #27, Beijing 100850, China.
  4. 4Institute of Infectious Disease, Henan Center for Disease Control and Prevention, Zhengzhou, Henan 450012, China.
  5. 5Beijing Mabworks Biotech Co. Ltd., No. 99, Kechuang 14th Street, Economic-Technological Development Area, Beijing 101111, China.
  6. 6Royal Free London NHS (National Health Service) Foundation Trust, Pond Street, London NW3 2QG, UK.
  7. 7National Institute for Infectious Diseases “Lazzaro Spallanzani,” Rome 00149, Italy.
  8. 8Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA.
  9. 9Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.
  10. 10National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China.
  11. 11CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, P.R. China.
  12. 12Mapp Biopharmaceutical Inc., San Diego, CA 92121, USA.
  13. 13Department of Immunology, University of Manitoba, Winnipeg, Manitoba R3E 0T5, Canada.
  14. 14Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104-4238, USA.
  1. *Corresponding author. E-mail: xiangguo.qiu{at}phac-aspc.gc.ca (X.Q.); gary.kobinger{at}phac-aspc.gc.ca (G.P.K.); fengjiannan77{at}qq.com (J.F.); zhangby{at}mab-works.com (B.Z.)
  • These authors contributed equally to this work.

  • Present address: CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, P.R. China.

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