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TarO-specific inhibitors of wall teichoic acid biosynthesis restore β-lactam efficacy against methicillin-resistant staphylococci

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Science Translational Medicine  09 Mar 2016:
Vol. 8, Issue 329, pp. 329ra32
DOI: 10.1126/scitranslmed.aad7364

Article Information

vol. 8 no. 329 329ra32

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication October 27, 2015
  • Accepted for publication February 19, 2016
  • .

Author Information

  1. Sang Ho Lee1,*,
  2. Hao Wang1,*,
  3. Marc Labroli2,
  4. Sandra Koseoglu1,
  5. Paul Zuck2,
  6. Todd Mayhood1,
  7. Charles Gill1,
  8. Paul Mann1,
  9. Xinwei Sher3,
  10. Sookhee Ha1,
  11. Shu-Wei Yang1,
  12. Mihir Mandal1,
  13. Christine Yang1,
  14. Lianzhu Liang1,
  15. Zheng Tan1,
  16. Paul Tawa1,
  17. Yan Hou1,
  18. Reshma Kuvelkar1,
  19. Kristine DeVito1,
  20. Xiujuan Wen1,
  21. Jing Xiao1,
  22. Michelle Batchlett2,
  23. Carl J. Balibar1,
  24. Jenny Liu1,
  25. Jianying Xiao1,
  26. Nicholas Murgolo1,
  27. Charles G. Garlisi1,
  28. Payal R. Sheth1,
  29. Amy Flattery1,
  30. Jing Su1,,
  31. Christopher Tan1, and
  32. Terry Roemer1,
  1. 1Merck Research Laboratories, Kenilworth, NJ 07033, USA.
  2. 2Merck Research Laboratories, West Point, PA 19486, USA.
  3. 3Merck Research Laboratories, Boston, MA 02115, USA.
  1. Corresponding author. E-mail: jing.su2{at}merck.com (J.S.); christopher_tan{at}merck.com (C.T.); terry_roemer{at}merck.com (T.R.)
    • * These authors contributed equally to this work.

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