Research ArticleBRAIN HEMORRHAGE

Therapeutic targeting of oxygen-sensing prolyl hydroxylases abrogates ATF4-dependent neuronal death and improves outcomes after brain hemorrhage in several rodent models

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Science Translational Medicine  02 Mar 2016:
Vol. 8, Issue 328, pp. 328ra29
DOI: 10.1126/scitranslmed.aac6008

Article Information

vol. 8 no. 328 328ra29

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History: 
  • Received for publication May 19, 2015
  • Accepted for publication February 12, 2016

Author Information

  1. Saravanan S. Karuppagounder1,2,
  2. Ishraq Alim1,2,
  3. Soah J. Khim1,2,
  4. Megan W. Bourassa1,2,
  5. Sama F. Sleiman1,2,
  6. Roseleen John3,
  7. Cyrille C. Thinnes4,
  8. Tzu-Lan Yeh4,
  9. Marina Demetriades4,
  10. Sandra Neitemeier5,
  11. Dana Cruz6,
  12. Irina Gazaryan1,2,
  13. David W. Killilea7,
  14. Lewis Morgenstern8,
  15. Guohua Xi9,
  16. Richard F. Keep9,
  17. Timothy Schallert10,
  18. Ryan V. Tappero11,
  19. Jian Zhong1,2,
  20. Sunghee Cho1,2,
  21. Frederick R. Maxfield6,
  22. Theodore R. Holman12,
  23. Carsten Culmsee5,
  24. Guo-Hua Fong13,
  25. Yijing Su14,
  26. Guo-li Ming14,
  27. Hongjun Song14,
  28. John W. Cave1,2,
  29. Christopher J. Schofield4,
  30. Frederick Colbourne3,
  31. Giovanni Coppola15 and
  32. Rajiv R. Ratan1,2,*
  1. 1Sperling Center for Hemorrhagic Stroke Recovery, Burke Medical Research Institute, White Plains, NY 10605, USA.
  2. 2Feil Family Brain and Mind Research Institute, Weill Medical College of Cornell University, New York, NY 10065, USA.
  3. 3Department of Psychology, University of Alberta, Edmonton, Alberta T6G 2E9, Canada.
  4. 4Department of Chemistry, University of Oxford, OX1 3TA Oxford, UK.
  5. 5Institut fuer Pharmakologie and Klinische Pharmazie, Phillips-Universitaet Marburg, D 35032 Marburg, Germany.
  6. 6Department of Biochemistry, Weill Medical College of Cornell University, New York, NY 10065, USA.
  7. 7Children’s Hospital of Oakland, Oakland, CA 94609, USA.
  8. 8Department of Neurology, University of Michigan, Ann Arbor, MI 48109, USA.
  9. 9Department of Neurosurgery, University of Michigan, Ann Arbor, MI 48109, USA.
  10. 10Department of Psychology, University of Texas at Austin, Austin, TX 78712, USA.
  11. 11Photon Sciences Directorate, Brookhaven National Laboratory, Upton, NY 11973, USA.
  12. 12Chemistry and Biochemistry, Department, University of California at Santa Cruz, Santa Cruz, CA 95064, USA.
  13. 13Center for Vascular Biology, University of Connecticut Health Center, Farmington, CT 06030, USA.
  14. 14Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
  15. 15Department of Psychiatry, University of California at Los Angeles, CA 90095, USA.
  1. *Corresponding author. E-mail: rrr2001{at}med.cornell.edu

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