Research ArticleCancer
ATRX loss promotes tumor growth and impairs nonhomologous end joining DNA repair in glioma
- Carl Koschmann1,2,
- Anda-Alexandra Calinescu2,
- Felipe J. Nunez2,
- Alan Mackay3,
- Janet Fazal-Salom3,
- Daniel Thomas2,
- Flor Mendez2,
- Neha Kamran2,
- Marta Dzaman2,
- Lakshman Mulpuri2,
- Johnathon Krasinkiewicz2,
- Robert Doherty2,
- Rosemary Lemons2,
- Jacqueline A. Brosnan-Cashman4,
- Youping Li2,
- Soyeon Roh2,
- Lili Zhao5,
- Henry Appelman6,
- David Ferguson6,
- Vera Gorbunova7,
- Alan Meeker8,
- Chris Jones3,
- Pedro R. Lowenstein2 and
- Maria G. Castro2,*
- 1Division of Pediatric Hematology-Oncology, Department of Pediatrics, University of Michigan School of Medicine, Ann Arbor, MI 48109, USA.
- 2Departments of Neurosurgery and Cell and Developmental Biology, University of Michigan School of Medicine, Ann Arbor, MI 48109, USA.
- 3Divisions of Molecular Pathology and Cancer Therapeutics, Institute of Cancer Research, London SM2 5NG, UK.
- 4Department of Pathology, Johns Hopkins University, Baltimore, MD 21287, USA.
- 5Department of Biostatistics, University of Michigan School of Medicine, Ann Arbor, MI 48109, USA.
- 6Department of Pathology, University of Michigan School of Medicine, Ann Arbor, MI 48109, USA.
- 7Department of Biology, University of Rochester, Rochester, NY 14627, USA.
- 8Departments of Pathology and Urology, Johns Hopkins University, Baltimore, MD 21287, USA.
- ↵*Corresponding author. E-mail: mariacas{at}med.umich.edu
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Science Translational Medicine 02 Mar 2016:
Vol. 8, Issue 328, pp. 328ra28
DOI: 10.1126/scitranslmed.aac8228
Vol. 8, Issue 328, pp. 328ra28
DOI: 10.1126/scitranslmed.aac8228
Carl Koschmann
1Division of Pediatric Hematology-Oncology, Department of Pediatrics, University of Michigan School of Medicine, Ann Arbor, MI 48109, USA.
2Departments of Neurosurgery and Cell and Developmental Biology, University of Michigan School of Medicine, Ann Arbor, MI 48109, USA.
Anda-Alexandra Calinescu
2Departments of Neurosurgery and Cell and Developmental Biology, University of Michigan School of Medicine, Ann Arbor, MI 48109, USA.
Felipe J. Nunez
2Departments of Neurosurgery and Cell and Developmental Biology, University of Michigan School of Medicine, Ann Arbor, MI 48109, USA.
Alan Mackay
3Divisions of Molecular Pathology and Cancer Therapeutics, Institute of Cancer Research, London SM2 5NG, UK.
Janet Fazal-Salom
3Divisions of Molecular Pathology and Cancer Therapeutics, Institute of Cancer Research, London SM2 5NG, UK.
Daniel Thomas
2Departments of Neurosurgery and Cell and Developmental Biology, University of Michigan School of Medicine, Ann Arbor, MI 48109, USA.
Flor Mendez
2Departments of Neurosurgery and Cell and Developmental Biology, University of Michigan School of Medicine, Ann Arbor, MI 48109, USA.
Neha Kamran
2Departments of Neurosurgery and Cell and Developmental Biology, University of Michigan School of Medicine, Ann Arbor, MI 48109, USA.
Marta Dzaman
2Departments of Neurosurgery and Cell and Developmental Biology, University of Michigan School of Medicine, Ann Arbor, MI 48109, USA.
Lakshman Mulpuri
2Departments of Neurosurgery and Cell and Developmental Biology, University of Michigan School of Medicine, Ann Arbor, MI 48109, USA.
Johnathon Krasinkiewicz
2Departments of Neurosurgery and Cell and Developmental Biology, University of Michigan School of Medicine, Ann Arbor, MI 48109, USA.
Robert Doherty
2Departments of Neurosurgery and Cell and Developmental Biology, University of Michigan School of Medicine, Ann Arbor, MI 48109, USA.
Rosemary Lemons
2Departments of Neurosurgery and Cell and Developmental Biology, University of Michigan School of Medicine, Ann Arbor, MI 48109, USA.
Jacqueline A. Brosnan-Cashman
4Department of Pathology, Johns Hopkins University, Baltimore, MD 21287, USA.
Youping Li
2Departments of Neurosurgery and Cell and Developmental Biology, University of Michigan School of Medicine, Ann Arbor, MI 48109, USA.
Soyeon Roh
2Departments of Neurosurgery and Cell and Developmental Biology, University of Michigan School of Medicine, Ann Arbor, MI 48109, USA.
Lili Zhao
5Department of Biostatistics, University of Michigan School of Medicine, Ann Arbor, MI 48109, USA.
Henry Appelman
6Department of Pathology, University of Michigan School of Medicine, Ann Arbor, MI 48109, USA.
David Ferguson
6Department of Pathology, University of Michigan School of Medicine, Ann Arbor, MI 48109, USA.
Vera Gorbunova
7Department of Biology, University of Rochester, Rochester, NY 14627, USA.
Alan Meeker
8Departments of Pathology and Urology, Johns Hopkins University, Baltimore, MD 21287, USA.
Chris Jones
3Divisions of Molecular Pathology and Cancer Therapeutics, Institute of Cancer Research, London SM2 5NG, UK.
Pedro R. Lowenstein
2Departments of Neurosurgery and Cell and Developmental Biology, University of Michigan School of Medicine, Ann Arbor, MI 48109, USA.
Maria G. Castro
2Departments of Neurosurgery and Cell and Developmental Biology, University of Michigan School of Medicine, Ann Arbor, MI 48109, USA.
