Contents
02 March 2016
Vol 8, Issue 328
Vol 8, Issue 328
Contents
Research Articles
- Dendritic cell vaccines based on immunogenic cell death elicit danger signals and T cell–driven rejection of high-grade glioma
Combining an immunogenic cell death inducer with dendritic cell immunotherapy treats high-grade glioma in a preclinical model.
- ATRX loss promotes tumor growth and impairs nonhomologous end joining DNA repair in glioma
The loss of ATRX impairs DNA repair, promoting glioma growth but enhancing sensitivity to DNA-damaging therapies.
- Therapeutic targeting of oxygen-sensing prolyl hydroxylases abrogates ATF4-dependent neuronal death and improves outcomes after brain hemorrhage in several rodent models
Blocking oxygen-sensing prolyl hydroxylases in the rodent CNS enhances functional recovery after brain hemorrhage.
- A dominant gain-of-function mutation in universal tyrosine kinase SRC causes thrombocytopenia, myelofibrosis, bleeding, and bone pathologies
E527K hyperactive SRC results in megakaryocytes with increased podosome formation, thrombocytopenia, myelofibrosis, bleeding, and bone pathologies.
Review
- PD-L1 (B7-H1) and PD-1 pathway blockade for cancer therapy: Mechanisms, response biomarkers, and combinations
PD pathway blockade elicits durable antitumor responses in a subset of patients with a broad spectrum of cancers.
Editors' Choice
- Smart CRISPR-Cas9 liver delivery repairs a genetic defect
CRISPR-Cas9 gene-editing technology efficiently corrects a defective liver enzyme in newborn mice with a severe metabolic disorder.
- Turning BiKEs into TriKEs to fight cancer
Incorporation of IL-15 into a bispecific antibody recognizing CD16 and CD33 boosted natural killer cells’ survival and activity against acute myeloid leukemia.
- Fluid dynamics of disease transmission
Studying the fluid dynamics of violent exhalations might hold the key to a better understanding of disease transmission—and its containment.
- Stressed-out dads can (metabolically) stress their kids
Paternal psychological stress induces hepatic gluconeogenesis and hyperglycemia in offspring.
- Could gut microbiota be the culprit?
The gut microbiome may predict development of pulmonary complications following allogeneic hematopoietic stem cell transplantation.
About The Cover
ONLINE COVER The Odd SRC. Shown is a healthy activated platelet. Turro et al. report that a gain-of-function mutation in the SRC cancer gene in humans leads to abnormal megakaryocyte and platelet formation, causing a rare bleeding disorder. [CREDIT: ROYALTYSTOCKPHOTO/ISTOCKPHOTO]