Research ArticleCancer

The tumor microenvironment and Immunoscore are critical determinants of dissemination to distant metastasis

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Science Translational Medicine  24 Feb 2016:
Vol. 8, Issue 327, pp. 327ra26
DOI: 10.1126/scitranslmed.aad6352

Article Information

vol. 8 no. 327 327ra26

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication October 14, 2015
  • Accepted for publication February 28, 2016
  • .

Author Information

  1. Bernhard Mlecnik1,2,3,*,
  2. Gabriela Bindea1,2,3,*,
  3. Amos Kirilovsky1,2,3,*,
  4. Helen K. Angell1,2,3,4,
  5. Anna C. Obenauf5,
  6. Marie Tosolini1,2,3,
  7. Sarah E. Church1,2,3,
  8. Pauline Maby1,2,3,
  9. Angela Vasaturo1,2,3,
  10. Mihaela Angelova1,2,3,
  11. Tessa Fredriksen1,2,3,
  12. Stéphanie Mauger1,2,3,
  13. Maximilian Waldner6,
  14. Anne Berger7,
  15. Michael R. Speicher5,
  16. Franck Pagès1,2,3,8,
  17. Viia Valge-Archer9 and
  18. Jérôme Galon1,2,3,
  1. 1INSERM, UMRS1138, Laboratory of Integrative Cancer Immunology, F-75006 Paris, France.
  2. 2Université Paris Descartes, Sorbonne Paris Cité, UMRS1138, F-75006 Paris, France.
  3. 3Sorbonne Universités, UPMC Univ Paris 06, UMRS1138, Centre de Recherche des Cordeliers, F-75006 Paris, France.
  4. 4AstraZeneca, Cambridge CB4 OWG, UK.
  5. 5Institute of Human Genetics, Medical University of Graz, Graz, Austria.
  6. 6Department of Medicine, University of Erlangen-Nuremberg, Erlangen, Germany.
  7. 7Assistance Publique–Hopitaux de Paris, Department of General and Digestive Surgery, Hôpital Européen Georges Pompidou, Paris, France.
  8. 8Assistance Publique–Hopitaux de Paris, Department of Immunology, Hôpital Européen Georges Pompidou, Paris, France.
  9. 9MedImmune Ltd., Cambridge CB21 GGH, UK.
  1. Corresponding author. E-mail: jerome.galon@crc.jussieu.fr
    • * These authors contributed equally to this work.

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