Research ArticleCancer

The tumor microenvironment and Immunoscore are critical determinants of dissemination to distant metastasis

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Science Translational Medicine  24 Feb 2016:
Vol. 8, Issue 327, pp. 327ra26
DOI: 10.1126/scitranslmed.aad6352

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Managing metastasis

Because of the poor prognosis of metastatic cancer, it is critical to determine exactly how different factors contribute to cancer spread. Mlecnik et al. examined the impact of tumor-intrinsic, microenvironmental, and immunological factors on tumor metastasis in colorectal cancer patients. They found that decreased presence of lymphatic vessels and reduced immune cytotoxicity were more strongly associated with the metastatic process than tumor-intrinsic factors such as chromosomal instability or cancer-associated mutations. These data support testing the Immunoscore as a biomarker to predict metastasis and guide therapy.

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