Research ArticleInfectious Disease

TLR-7 activation enhances IL-22–mediated colonization resistance against vancomycin-resistant enterococcus

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Science Translational Medicine  24 Feb 2016:
Vol. 8, Issue 327, pp. 327ra25
DOI: 10.1126/scitranslmed.aad6663

Combating antibiotic resistance

Antibiotics are the front line of defense against many bacterial infections, but antibiotics also disrupt the intestinal microbiota, which provides a barrier against colonization by other pathogens, such as vancomycin-resistant Enterococcus faecium (VRE). Abt et al. now find that a synthetic ligand for Toll-like receptor 7 stimulates antiviral innate immune responses in the intestine similar to viral infection, restoring colonization resistance to VRE. Thus, this orally bioavailable therapy may serve to limit infection by intestinal pathogens in antibiotic-exposed, susceptible individuals.

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