Contents
24 February 2016
Vol 8, Issue 327
Vol 8, Issue 327
Contents
Focus
- Eco-evolution of cancer resistance
Contrary to high-dose cytotoxic chemotherapy, where they proliferate unopposed, drug-resistant cancer cells may be at an evolutionary disadvantage in presence of low-dose chemotherapy owing to the high metabolic cost of their resistance mechanisms (Enriquez-Navas et al., this issue).
Perspective
- Buying cures versus renting health: Financing health care with consumer loans
Health care loans—the equivalent of mortgages for large health care expenses—are a practical way to increase patient access to costly transformative therapies.
Research Articles
- Exploiting evolutionary principles to prolong tumor control in preclinical models of breast cancer
Using evolutionary principles to guide drug administration, monotherapy with paclitaxel can maintain prolonged stability of breast cancer in preclinical models.
- TLR-7 activation enhances IL-22–mediated colonization resistance against vancomycin-resistant enterococcus
A synthetic TLR-7 agonist restores immune defenses to an antibiotic-resistant pathogen lost due to antibiotic use.
- The tumor microenvironment and Immunoscore are critical determinants of dissemination to distant metastasis
Local lymphatic vessel density and immune cytotoxicity prevent metastatic invasion.
Editors' Choice
- Resting and gestating
Sleep and inflammation may mediate the relationship between nutrition and gestational length.
- Genetic study of schizophrenia returns the complement
Genetic variation in human complement component 4 (C4) genes contributes to schizophrenia risk.
- Infections with benefits
Gastric Helicobacter pylori infection, which has paradoxical effects on human health, alters the immune environment and microbiota.
- Balance of nutrients: Is more better?
Changes in maternal plasma folate concentrations affect genome-wide DNA methylation status of the fetus.
- Can prenatal infection contribute to psychiatric disease in offspring?
Immune activation in pregnant mice leads to both impaired GABAergic transmission and increased anxiety-like behaviors in adult offspring.
About The Cover
ONLINE COVER Protecting Against Metastasis. Notre Dame de Paris gargoyles guard over the city of Paris to frighten off and protect from any evil or harmful spirits. In this issue of Science Translational Medicine, Mlecnik et al. describe the protective role of cytotoxic immune infiltrate, Immunoscore, and lymphatic vessels against metastatic invasion in human cancer. These results support the use of T cell based immunotherapy at early stage disease. [CREDIT: Julian Elliott/robertharding/Corbis]