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Research ArticleCARDIAC HYPERTROPHY
Long noncoding RNA Chast promotes cardiac remodeling
- Janika Viereck1,2,*,
- Regalla Kumarswamy1,*,
- Ariana Foinquinos1,*,
- Ke Xiao1,
- Petros Avramopoulos3,4,
- Meik Kunz5,
- Marcus Dittrich5,6,
- Tobias Maetzig7,
- Karina Zimmer1,
- Janet Remke1,
- Annette Just1,
- Jasmin Fendrich1,
- Kristian Scherf1,
- Emiliano Bolesani8,
- Axel Schambach7,
- Frank Weidemann9,10,
- Robert Zweigerdt8,
- Leon J. de Windt11,
- Stefan Engelhardt3,4,
- Thomas Dandekar5,
- Sandor Batkai1 and
- Thomas Thum1,2,12,†
- 1Institute of Molecular and Translational Therapeutic Strategies (IMTTS), Integriertes Forschungs- und Behandlungszentrum Transplantation (IFB-Tx), Hannover Medical School, D-30625 Hannover, Germany.
- 2Excellence Cluster REBIRTH, Hannover Medical School, D-30625 Hannover, Germany.
- 3Institute of Pharmacology and Toxicology, Technical University of Munich, D-80802 Munich, Germany.
- 4German Center for Cardiovascular Research (DZHK), partner site Munich Heart Alliance, D-80802 Munich, Germany.
- 5Department of Bioinformatics, University of Würzburg, D-97074 Würzburg, Germany.
- 6Institute of Human Genetics, University of Würzburg, D-97074 Würzburg, Germany.
- 7Institute of Experimental Hematology, Hannover Medical School, D-30625 Hannover, Germany.
- 8Leibniz Research Laboratories for Biotechnology and Artificial Organs (LEBAO), Department of Cardiac, Thoracic, Transplantation and Vascular Surgery, Hannover Medical School, D-30625 Hannover, Germany.
- 9Department of Cardiology, Julius-Maximilians University, D-97080 Würzburg, Germany.
- 10Comprehensive Heart Failure Center, University of Würzburg, D-97078 Würzburg, Germany.
- 11Department of Cardiology, Maastricht University, 6202 AZ Maastricht, Netherlands.
- 12National Heart and Lung Institute, Imperial College London, SW3 6NP London, UK.
- ↵†Corresponding author. E-mail: thum.thomas{at}mh-hannover.de
↵* These authors contributed equally to this work.
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Science Translational Medicine 17 Feb 2016:
Vol. 8, Issue 326, pp. 326ra22
DOI: 10.1126/scitranslmed.aaf1475
Vol. 8, Issue 326, pp. 326ra22
DOI: 10.1126/scitranslmed.aaf1475
Janika Viereck
1Institute of Molecular and Translational Therapeutic Strategies (IMTTS), Integriertes Forschungs- und Behandlungszentrum Transplantation (IFB-Tx), Hannover Medical School, D-30625 Hannover, Germany.
2Excellence Cluster REBIRTH, Hannover Medical School, D-30625 Hannover, Germany.
Regalla Kumarswamy
1Institute of Molecular and Translational Therapeutic Strategies (IMTTS), Integriertes Forschungs- und Behandlungszentrum Transplantation (IFB-Tx), Hannover Medical School, D-30625 Hannover, Germany.
Ariana Foinquinos
1Institute of Molecular and Translational Therapeutic Strategies (IMTTS), Integriertes Forschungs- und Behandlungszentrum Transplantation (IFB-Tx), Hannover Medical School, D-30625 Hannover, Germany.
Ke Xiao
1Institute of Molecular and Translational Therapeutic Strategies (IMTTS), Integriertes Forschungs- und Behandlungszentrum Transplantation (IFB-Tx), Hannover Medical School, D-30625 Hannover, Germany.
Petros Avramopoulos
3Institute of Pharmacology and Toxicology, Technical University of Munich, D-80802 Munich, Germany.
4German Center for Cardiovascular Research (DZHK), partner site Munich Heart Alliance, D-80802 Munich, Germany.
Meik Kunz
5Department of Bioinformatics, University of Würzburg, D-97074 Würzburg, Germany.
Marcus Dittrich
5Department of Bioinformatics, University of Würzburg, D-97074 Würzburg, Germany.
6Institute of Human Genetics, University of Würzburg, D-97074 Würzburg, Germany.
Tobias Maetzig
7Institute of Experimental Hematology, Hannover Medical School, D-30625 Hannover, Germany.
Karina Zimmer
1Institute of Molecular and Translational Therapeutic Strategies (IMTTS), Integriertes Forschungs- und Behandlungszentrum Transplantation (IFB-Tx), Hannover Medical School, D-30625 Hannover, Germany.
Janet Remke
1Institute of Molecular and Translational Therapeutic Strategies (IMTTS), Integriertes Forschungs- und Behandlungszentrum Transplantation (IFB-Tx), Hannover Medical School, D-30625 Hannover, Germany.
Annette Just
1Institute of Molecular and Translational Therapeutic Strategies (IMTTS), Integriertes Forschungs- und Behandlungszentrum Transplantation (IFB-Tx), Hannover Medical School, D-30625 Hannover, Germany.
Jasmin Fendrich
1Institute of Molecular and Translational Therapeutic Strategies (IMTTS), Integriertes Forschungs- und Behandlungszentrum Transplantation (IFB-Tx), Hannover Medical School, D-30625 Hannover, Germany.
Kristian Scherf
1Institute of Molecular and Translational Therapeutic Strategies (IMTTS), Integriertes Forschungs- und Behandlungszentrum Transplantation (IFB-Tx), Hannover Medical School, D-30625 Hannover, Germany.
Emiliano Bolesani
8Leibniz Research Laboratories for Biotechnology and Artificial Organs (LEBAO), Department of Cardiac, Thoracic, Transplantation and Vascular Surgery, Hannover Medical School, D-30625 Hannover, Germany.
Axel Schambach
7Institute of Experimental Hematology, Hannover Medical School, D-30625 Hannover, Germany.
Frank Weidemann
9Department of Cardiology, Julius-Maximilians University, D-97080 Würzburg, Germany.
10Comprehensive Heart Failure Center, University of Würzburg, D-97078 Würzburg, Germany.
Robert Zweigerdt
8Leibniz Research Laboratories for Biotechnology and Artificial Organs (LEBAO), Department of Cardiac, Thoracic, Transplantation and Vascular Surgery, Hannover Medical School, D-30625 Hannover, Germany.
Leon J. de Windt
11Department of Cardiology, Maastricht University, 6202 AZ Maastricht, Netherlands.
Stefan Engelhardt
3Institute of Pharmacology and Toxicology, Technical University of Munich, D-80802 Munich, Germany.
4German Center for Cardiovascular Research (DZHK), partner site Munich Heart Alliance, D-80802 Munich, Germany.
Thomas Dandekar
5Department of Bioinformatics, University of Würzburg, D-97074 Würzburg, Germany.
Sandor Batkai
1Institute of Molecular and Translational Therapeutic Strategies (IMTTS), Integriertes Forschungs- und Behandlungszentrum Transplantation (IFB-Tx), Hannover Medical School, D-30625 Hannover, Germany.
Thomas Thum
1Institute of Molecular and Translational Therapeutic Strategies (IMTTS), Integriertes Forschungs- und Behandlungszentrum Transplantation (IFB-Tx), Hannover Medical School, D-30625 Hannover, Germany.
2Excellence Cluster REBIRTH, Hannover Medical School, D-30625 Hannover, Germany.
12National Heart and Lung Institute, Imperial College London, SW3 6NP London, UK.
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