Long noncoding RNA Chast promotes cardiac remodeling

Janika Viereck; Regalla Kumarswamy; Ariana Foinquinos; Ke Xiao; Petros Avramopoulos; Meik Kunz; Marcus Dittrich; Tobias Maetzig; Karina Zimmer; Janet Remke; Annette Just; Jasmin Fendrich; Kristian Scherf; Emiliano Bolesani; Axel Schambach; Frank Weidemann; Robert Zweigerdt; Leon J. de Windt; Stefan Engelhardt; Thomas Dandekar; Sandor Batkai; Thomas Thum

doi:10.1126/scitranslmed.aaf1475

Research ArticleCARDIAC HYPERTROPHY

Long noncoding RNA Chast promotes cardiac remodeling

Janika Viereck¹,²,*,
Regalla Kumarswamy¹,*,
Ariana Foinquinos¹,*,
Ke Xiao¹,
Petros Avramopoulos³,⁴,
Meik Kunz⁵,
Marcus Dittrich⁵,⁶,
Tobias Maetzig⁷,
Karina Zimmer¹,
Janet Remke¹,
Annette Just¹,
Jasmin Fendrich¹,
Kristian Scherf¹,
Emiliano Bolesani⁸,
Axel Schambach⁷,
Frank Weidemann⁹,¹⁰,
Robert Zweigerdt⁸,
Leon J. de Windt¹¹,
Stefan Engelhardt³,⁴,
Thomas Dandekar⁵,
Sandor Batkai¹ and
Thomas Thum¹,²,¹²,†

¹Institute of Molecular and Translational Therapeutic Strategies (IMTTS), Integriertes Forschungs- und Behandlungszentrum Transplantation (IFB-Tx), Hannover Medical School, D-30625 Hannover, Germany.
²Excellence Cluster REBIRTH, Hannover Medical School, D-30625 Hannover, Germany.
³Institute of Pharmacology and Toxicology, Technical University of Munich, D-80802 Munich, Germany.
⁴German Center for Cardiovascular Research (DZHK), partner site Munich Heart Alliance, D-80802 Munich, Germany.
⁵Department of Bioinformatics, University of Würzburg, D-97074 Würzburg, Germany.
⁶Institute of Human Genetics, University of Würzburg, D-97074 Würzburg, Germany.
⁷Institute of Experimental Hematology, Hannover Medical School, D-30625 Hannover, Germany.
⁸Leibniz Research Laboratories for Biotechnology and Artificial Organs (LEBAO), Department of Cardiac, Thoracic, Transplantation and Vascular Surgery, Hannover Medical School, D-30625 Hannover, Germany.
⁹Department of Cardiology, Julius-Maximilians University, D-97080 Würzburg, Germany.
¹⁰Comprehensive Heart Failure Center, University of Würzburg, D-97078 Würzburg, Germany.
¹¹Department of Cardiology, Maastricht University, 6202 AZ Maastricht, Netherlands.
¹²National Heart and Lung Institute, Imperial College London, SW3 6NP London, UK.

↵†Corresponding author. E-mail: thum.thomas{at}mh-hannover.de

↵* These authors contributed equally to this work.

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Science Translational Medicine 17 Feb 2016:
Vol. 8, Issue 326, pp. 326ra22
DOI: 10.1126/scitranslmed.aaf1475

Janika Viereck

1Institute of Molecular and Translational Therapeutic Strategies (IMTTS), Integriertes Forschungs- und Behandlungszentrum Transplantation (IFB-Tx), Hannover Medical School, D-30625 Hannover, Germany.

2Excellence Cluster REBIRTH, Hannover Medical School, D-30625 Hannover, Germany.

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Regalla Kumarswamy

1Institute of Molecular and Translational Therapeutic Strategies (IMTTS), Integriertes Forschungs- und Behandlungszentrum Transplantation (IFB-Tx), Hannover Medical School, D-30625 Hannover, Germany.

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Ariana Foinquinos

1Institute of Molecular and Translational Therapeutic Strategies (IMTTS), Integriertes Forschungs- und Behandlungszentrum Transplantation (IFB-Tx), Hannover Medical School, D-30625 Hannover, Germany.

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Ke Xiao

1Institute of Molecular and Translational Therapeutic Strategies (IMTTS), Integriertes Forschungs- und Behandlungszentrum Transplantation (IFB-Tx), Hannover Medical School, D-30625 Hannover, Germany.

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Petros Avramopoulos

3Institute of Pharmacology and Toxicology, Technical University of Munich, D-80802 Munich, Germany.

4German Center for Cardiovascular Research (DZHK), partner site Munich Heart Alliance, D-80802 Munich, Germany.

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Meik Kunz

5Department of Bioinformatics, University of Würzburg, D-97074 Würzburg, Germany.

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Marcus Dittrich

5Department of Bioinformatics, University of Würzburg, D-97074 Würzburg, Germany.

6Institute of Human Genetics, University of Würzburg, D-97074 Würzburg, Germany.

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Tobias Maetzig

7Institute of Experimental Hematology, Hannover Medical School, D-30625 Hannover, Germany.

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Karina Zimmer

1Institute of Molecular and Translational Therapeutic Strategies (IMTTS), Integriertes Forschungs- und Behandlungszentrum Transplantation (IFB-Tx), Hannover Medical School, D-30625 Hannover, Germany.

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Janet Remke

1Institute of Molecular and Translational Therapeutic Strategies (IMTTS), Integriertes Forschungs- und Behandlungszentrum Transplantation (IFB-Tx), Hannover Medical School, D-30625 Hannover, Germany.

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Annette Just

1Institute of Molecular and Translational Therapeutic Strategies (IMTTS), Integriertes Forschungs- und Behandlungszentrum Transplantation (IFB-Tx), Hannover Medical School, D-30625 Hannover, Germany.

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Jasmin Fendrich

1Institute of Molecular and Translational Therapeutic Strategies (IMTTS), Integriertes Forschungs- und Behandlungszentrum Transplantation (IFB-Tx), Hannover Medical School, D-30625 Hannover, Germany.

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Kristian Scherf

1Institute of Molecular and Translational Therapeutic Strategies (IMTTS), Integriertes Forschungs- und Behandlungszentrum Transplantation (IFB-Tx), Hannover Medical School, D-30625 Hannover, Germany.

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Emiliano Bolesani

8Leibniz Research Laboratories for Biotechnology and Artificial Organs (LEBAO), Department of Cardiac, Thoracic, Transplantation and Vascular Surgery, Hannover Medical School, D-30625 Hannover, Germany.

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Axel Schambach

7Institute of Experimental Hematology, Hannover Medical School, D-30625 Hannover, Germany.

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Frank Weidemann

9Department of Cardiology, Julius-Maximilians University, D-97080 Würzburg, Germany.

10Comprehensive Heart Failure Center, University of Würzburg, D-97078 Würzburg, Germany.

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Robert Zweigerdt

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Leon J. de Windt

11Department of Cardiology, Maastricht University, 6202 AZ Maastricht, Netherlands.

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Stefan Engelhardt

3Institute of Pharmacology and Toxicology, Technical University of Munich, D-80802 Munich, Germany.

4German Center for Cardiovascular Research (DZHK), partner site Munich Heart Alliance, D-80802 Munich, Germany.

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Thomas Dandekar

5Department of Bioinformatics, University of Würzburg, D-97074 Würzburg, Germany.

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Sandor Batkai

1Institute of Molecular and Translational Therapeutic Strategies (IMTTS), Integriertes Forschungs- und Behandlungszentrum Transplantation (IFB-Tx), Hannover Medical School, D-30625 Hannover, Germany.

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Thomas Thum

1Institute of Molecular and Translational Therapeutic Strategies (IMTTS), Integriertes Forschungs- und Behandlungszentrum Transplantation (IFB-Tx), Hannover Medical School, D-30625 Hannover, Germany.

2Excellence Cluster REBIRTH, Hannover Medical School, D-30625 Hannover, Germany.

12National Heart and Lung Institute, Imperial College London, SW3 6NP London, UK.

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For correspondence: thum.thomas@mh-hannover.de

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Long noncoding RNA Chast promotes cardiac remodeling

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