Human polyclonal immunoglobulin G from transchromosomic bovines inhibits MERS-CoV in vivo

Thomas Luke; Hua Wu; Jincun Zhao; Rudragouda Channappanavar; Christopher M. Coleman; Jin-An Jiao; Hiroaki Matsushita; Ye Liu; Elena N. Postnikova; Britini L. Ork; Gregory Glenn; David Flyer; Gabriel Defang; Kanakatte Raviprakash; Tadeusz Kochel; Jonathan Wang; Wensheng Nie; Gale Smith; Lisa E. Hensley; Gene G. Olinger; Jens H. Kuhn; Michael R. Holbrook; Reed F. Johnson; Stanley Perlman; Eddie Sullivan; Matthew B. Frieman

doi:10.1126/scitranslmed.aaf1061

Research ArticleInfectious Disease

Human polyclonal immunoglobulin G from transchromosomic bovines inhibits MERS-CoV in vivo

Thomas Luke¹,*,
Hua Wu²,
Jincun Zhao³,⁴,
Rudragouda Channappanavar³,
Christopher M. Coleman⁵,
Jin-An Jiao²,
Hiroaki Matsushita²,
Ye Liu⁶,
Elena N. Postnikova⁷,
Britini L. Ork⁷,
Gregory Glenn⁶,
David Flyer⁶,
Gabriel Defang⁸,
Kanakatte Raviprakash⁹,
Tadeusz Kochel⁹,†,
Jonathan Wang¹⁰,
Wensheng Nie¹⁰,
Gale Smith⁶,
Lisa E. Hensley⁷,
Gene G. Olinger⁷,
Jens H. Kuhn⁷,
Michael R. Holbrook⁷,
Reed F. Johnson¹¹,
Stanley Perlman³,
Eddie Sullivan² and
Matthew B. Frieman⁵

¹Viral and Rickettsial Diseases Department, Navy Medical Research Center, The Henry Jackson Foundation for the Advancement of Military Medicine, Silver Spring, MD 20910, USA.
²SAB Biotherapeutics Inc., Sioux Falls, SD 57104, USA.
³Department of Microbiology, University of Iowa, Iowa City, IA 52242, USA.
⁴State Key Laboratory of Respiratory Diseases, Guangzhou Institute of Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510120, China.
⁵Department of Microbiology and Immunology, University of Maryland, School of Medicine, Baltimore, MD 21201, USA.
⁶Novavax Inc., Gaithersburg, MD 20878, USA.
⁷Integrated Research Facility at Fort Detrick, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, MD 21702, USA.
⁸Department of Virology, Naval Medical Research Unit-3, Cairo FPO AP 09835, Egypt.
⁹Viral and Rickettsial Diseases Department, Navy Medical Research Center, Silver Spring, MD 20910, USA.
¹⁰Thermo Fisher Scientific, South San Francisco, CA 94080, USA.
¹¹Emerging Viral Pathogens Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, MD 21702, USA.

↵*Corresponding author. E-mail: thomas.c.luke.ctr{at}mail.mil

↵† Present address: Forensic Virology, National Biodefense Analysis and Countermeasures Center, Frederick, MD 21702, USA.

See allHide authors and affiliations

Science Translational Medicine 17 Feb 2016:
Vol. 8, Issue 326, pp. 326ra21
DOI: 10.1126/scitranslmed.aaf1061

Thomas Luke

Viral and Rickettsial Diseases Department, Navy Medical Research Center, The Henry Jackson Foundation for the Advancement of Military Medicine, Silver Spring, MD 20910, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Hua Wu

SAB Biotherapeutics Inc., Sioux Falls, SD 57104, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Jincun Zhao

Department of Microbiology, University of Iowa, Iowa City, IA 52242, USA.State Key Laboratory of Respiratory Diseases, Guangzhou Institute of Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510120, China.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Rudragouda Channappanavar

Department of Microbiology, University of Iowa, Iowa City, IA 52242, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Christopher M. Coleman

Department of Microbiology and Immunology, University of Maryland, School of Medicine, Baltimore, MD 21201, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Jin-An Jiao

SAB Biotherapeutics Inc., Sioux Falls, SD 57104, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Hiroaki Matsushita

SAB Biotherapeutics Inc., Sioux Falls, SD 57104, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Ye Liu

Novavax Inc., Gaithersburg, MD 20878, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Elena N. Postnikova

Integrated Research Facility at Fort Detrick, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, MD 21702, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Britini L. Ork

Integrated Research Facility at Fort Detrick, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, MD 21702, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Gregory Glenn

Novavax Inc., Gaithersburg, MD 20878, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

David Flyer

Novavax Inc., Gaithersburg, MD 20878, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Gabriel Defang

Department of Virology, Naval Medical Research Unit-3, Cairo FPO AP 09835, Egypt.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Kanakatte Raviprakash

Department of Virology, Naval Medical Research Unit-3, Cairo FPO AP 09835, Egypt.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Tadeusz Kochel

Viral and Rickettsial Diseases Department, Navy Medical Research Center, Silver Spring, MD 20910, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
For correspondence: thomas.c.luke.ctr@mail.mil

Jonathan Wang

Thermo Fisher Scientific, South San Francisco, CA 94080, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Wensheng Nie

Thermo Fisher Scientific, South San Francisco, CA 94080, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Gale Smith

Novavax Inc., Gaithersburg, MD 20878, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Lisa E. Hensley

Integrated Research Facility at Fort Detrick, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, MD 21702, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Gene G. Olinger

Integrated Research Facility at Fort Detrick, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, MD 21702, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Jens H. Kuhn

Integrated Research Facility at Fort Detrick, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, MD 21702, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Michael R. Holbrook

Integrated Research Facility at Fort Detrick, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, MD 21702, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Reed F. Johnson

Emerging Viral Pathogens Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, MD 21702, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Stanley Perlman

Department of Microbiology, University of Iowa, Iowa City, IA 52242, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Eddie Sullivan

SAB Biotherapeutics Inc., Sioux Falls, SD 57104, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Matthew B. Frieman

Department of Microbiology and Immunology, University of Maryland, School of Medicine, Baltimore, MD 21201, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Article
Figures & Data
Info & Metrics
eLetters
PDF

eLetters is an online forum for ongoing peer review. Submission of eLetters are open to all. Please read our Terms of Service before submitting your own eLetter.

Submit a Response to This Article

Compose eLetter

Title

Contents

More information about text formats

Plain text

Plain text
No HTML tags allowed.
Web page addresses and e-mail addresses turn into links automatically.
Lines and paragraphs break automatically.

Author Information

Contributors
First name and middle name First or given name, e.g. 'Peter'. Last Name Your last, or family, name, e.g. 'MacMoody'. Email Your email address, e.g. higgs-boson@gmail.com Role / Occupation Your role and/or occupation, e.g. 'Orthopedic Surgeon'. Affiliation Your organization or institution (if applicable), e.g. 'Royal Free Hospital'.

Statement of Competing Interests

Competing interests?

Yes

Please describe the competing interests

CAPTCHA

This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.

What code is in the image? Enter the characters shown in the image.

Vertical Tabs

No eLetters have been published for this article.

View Full Text

Human polyclonal immunoglobulin G from transchromosomic bovines inhibits MERS-CoV in vivo

Plain text

Vertical Tabs

Science Translational Medicine

Article Tools