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Research ArticleInfectious Disease
Human polyclonal immunoglobulin G from transchromosomic bovines inhibits MERS-CoV in vivo
- Thomas Luke1,*,
- Hua Wu2,
- Jincun Zhao3,4,
- Rudragouda Channappanavar3,
- Christopher M. Coleman5,
- Jin-An Jiao2,
- Hiroaki Matsushita2,
- Ye Liu6,
- Elena N. Postnikova7,
- Britini L. Ork7,
- Gregory Glenn6,
- David Flyer6,
- Gabriel Defang8,
- Kanakatte Raviprakash9,
- Tadeusz Kochel9,†,
- Jonathan Wang10,
- Wensheng Nie10,
- Gale Smith6,
- Lisa E. Hensley7,
- Gene G. Olinger7,
- Jens H. Kuhn7,
- Michael R. Holbrook7,
- Reed F. Johnson11,
- Stanley Perlman3,
- Eddie Sullivan2 and
- Matthew B. Frieman5
- 1Viral and Rickettsial Diseases Department, Navy Medical Research Center, The Henry Jackson Foundation for the Advancement of Military Medicine, Silver Spring, MD 20910, USA.
- 2SAB Biotherapeutics Inc., Sioux Falls, SD 57104, USA.
- 3Department of Microbiology, University of Iowa, Iowa City, IA 52242, USA.
- 4State Key Laboratory of Respiratory Diseases, Guangzhou Institute of Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510120, China.
- 5Department of Microbiology and Immunology, University of Maryland, School of Medicine, Baltimore, MD 21201, USA.
- 6Novavax Inc., Gaithersburg, MD 20878, USA.
- 7Integrated Research Facility at Fort Detrick, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, MD 21702, USA.
- 8Department of Virology, Naval Medical Research Unit-3, Cairo FPO AP 09835, Egypt.
- 9Viral and Rickettsial Diseases Department, Navy Medical Research Center, Silver Spring, MD 20910, USA.
- 10Thermo Fisher Scientific, South San Francisco, CA 94080, USA.
- 11Emerging Viral Pathogens Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, MD 21702, USA.
- ↵*Corresponding author. E-mail: thomas.c.luke.ctr{at}mail.mil
↵† Present address: Forensic Virology, National Biodefense Analysis and Countermeasures Center, Frederick, MD 21702, USA.
See allHide authors and affiliations
Science Translational Medicine 17 Feb 2016:
Vol. 8, Issue 326, pp. 326ra21
DOI: 10.1126/scitranslmed.aaf1061
Vol. 8, Issue 326, pp. 326ra21
DOI: 10.1126/scitranslmed.aaf1061
Thomas Luke
1Viral and Rickettsial Diseases Department, Navy Medical Research Center, The Henry Jackson Foundation for the Advancement of Military Medicine, Silver Spring, MD 20910, USA.
Hua Wu
2SAB Biotherapeutics Inc., Sioux Falls, SD 57104, USA.
Jincun Zhao
3Department of Microbiology, University of Iowa, Iowa City, IA 52242, USA.
4State Key Laboratory of Respiratory Diseases, Guangzhou Institute of Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510120, China.
Rudragouda Channappanavar
3Department of Microbiology, University of Iowa, Iowa City, IA 52242, USA.
Christopher M. Coleman
5Department of Microbiology and Immunology, University of Maryland, School of Medicine, Baltimore, MD 21201, USA.
Jin-An Jiao
2SAB Biotherapeutics Inc., Sioux Falls, SD 57104, USA.
Hiroaki Matsushita
2SAB Biotherapeutics Inc., Sioux Falls, SD 57104, USA.
Ye Liu
6Novavax Inc., Gaithersburg, MD 20878, USA.
Elena N. Postnikova
7Integrated Research Facility at Fort Detrick, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, MD 21702, USA.
Britini L. Ork
7Integrated Research Facility at Fort Detrick, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, MD 21702, USA.
Gregory Glenn
6Novavax Inc., Gaithersburg, MD 20878, USA.
David Flyer
6Novavax Inc., Gaithersburg, MD 20878, USA.
Gabriel Defang
8Department of Virology, Naval Medical Research Unit-3, Cairo FPO AP 09835, Egypt.
Kanakatte Raviprakash
8Department of Virology, Naval Medical Research Unit-3, Cairo FPO AP 09835, Egypt.
Tadeusz Kochel
9Viral and Rickettsial Diseases Department, Navy Medical Research Center, Silver Spring, MD 20910, USA.
Jonathan Wang
10Thermo Fisher Scientific, South San Francisco, CA 94080, USA.
Wensheng Nie
10Thermo Fisher Scientific, South San Francisco, CA 94080, USA.
Gale Smith
6Novavax Inc., Gaithersburg, MD 20878, USA.
Lisa E. Hensley
7Integrated Research Facility at Fort Detrick, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, MD 21702, USA.
Gene G. Olinger
7Integrated Research Facility at Fort Detrick, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, MD 21702, USA.
Jens H. Kuhn
7Integrated Research Facility at Fort Detrick, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, MD 21702, USA.
Michael R. Holbrook
7Integrated Research Facility at Fort Detrick, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, MD 21702, USA.
Reed F. Johnson
11Emerging Viral Pathogens Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, MD 21702, USA.
Stanley Perlman
3Department of Microbiology, University of Iowa, Iowa City, IA 52242, USA.
Eddie Sullivan
2SAB Biotherapeutics Inc., Sioux Falls, SD 57104, USA.
Matthew B. Frieman
5Department of Microbiology and Immunology, University of Maryland, School of Medicine, Baltimore, MD 21201, USA.
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