Human polyclonal immunoglobulin G from transchromosomic bovines inhibits MERS-CoV in vivo

Thomas Luke; Hua Wu; Jincun Zhao; Rudragouda Channappanavar; Christopher M. Coleman; Jin-An Jiao; Hiroaki Matsushita; Ye Liu; Elena N. Postnikova; Britini L. Ork; Gregory Glenn; David Flyer; Gabriel Defang; Kanakatte Raviprakash; Tadeusz Kochel; Jonathan Wang; Wensheng Nie; Gale Smith; Lisa E. Hensley; Gene G. Olinger; Jens H. Kuhn; Michael R. Holbrook; Reed F. Johnson; Stanley Perlman; Eddie Sullivan; Matthew B. Frieman

doi:10.1126/scitranslmed.aaf1061

Research ArticleInfectious Disease

Human polyclonal immunoglobulin G from transchromosomic bovines inhibits MERS-CoV in vivo

Thomas Luke¹,*,
Hua Wu²,
Jincun Zhao³,⁴,
Rudragouda Channappanavar³,
Christopher M. Coleman⁵,
Jin-An Jiao²,
Hiroaki Matsushita²,
Ye Liu⁶,
Elena N. Postnikova⁷,
Britini L. Ork⁷,
Gregory Glenn⁶,
David Flyer⁶,
Gabriel Defang⁸,
Kanakatte Raviprakash⁹,
Tadeusz Kochel⁹,†,
Jonathan Wang¹⁰,
Wensheng Nie¹⁰,
Gale Smith⁶,
Lisa E. Hensley⁷,
Gene G. Olinger⁷,
Jens H. Kuhn⁷,
Michael R. Holbrook⁷,
Reed F. Johnson¹¹,
Stanley Perlman³,
Eddie Sullivan² and
Matthew B. Frieman⁵

¹Viral and Rickettsial Diseases Department, Navy Medical Research Center, The Henry Jackson Foundation for the Advancement of Military Medicine, Silver Spring, MD 20910, USA.
²SAB Biotherapeutics Inc., Sioux Falls, SD 57104, USA.
³Department of Microbiology, University of Iowa, Iowa City, IA 52242, USA.
⁴State Key Laboratory of Respiratory Diseases, Guangzhou Institute of Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510120, China.
⁵Department of Microbiology and Immunology, University of Maryland, School of Medicine, Baltimore, MD 21201, USA.
⁶Novavax Inc., Gaithersburg, MD 20878, USA.
⁷Integrated Research Facility at Fort Detrick, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, MD 21702, USA.
⁸Department of Virology, Naval Medical Research Unit-3, Cairo FPO AP 09835, Egypt.
⁹Viral and Rickettsial Diseases Department, Navy Medical Research Center, Silver Spring, MD 20910, USA.
¹⁰Thermo Fisher Scientific, South San Francisco, CA 94080, USA.
¹¹Emerging Viral Pathogens Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, MD 21702, USA.

↵*Corresponding author. E-mail: thomas.c.luke.ctr{at}mail.mil

↵† Present address: Forensic Virology, National Biodefense Analysis and Countermeasures Center, Frederick, MD 21702, USA.

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Science Translational Medicine 17 Feb 2016:
Vol. 8, Issue 326, pp. 326ra21
DOI: 10.1126/scitranslmed.aaf1061

Thomas Luke

1Viral and Rickettsial Diseases Department, Navy Medical Research Center, The Henry Jackson Foundation for the Advancement of Military Medicine, Silver Spring, MD 20910, USA.

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Hua Wu

2SAB Biotherapeutics Inc., Sioux Falls, SD 57104, USA.

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Jincun Zhao

3Department of Microbiology, University of Iowa, Iowa City, IA 52242, USA.

4State Key Laboratory of Respiratory Diseases, Guangzhou Institute of Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510120, China.

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Rudragouda Channappanavar

3Department of Microbiology, University of Iowa, Iowa City, IA 52242, USA.

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Christopher M. Coleman

5Department of Microbiology and Immunology, University of Maryland, School of Medicine, Baltimore, MD 21201, USA.

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Jin-An Jiao

2SAB Biotherapeutics Inc., Sioux Falls, SD 57104, USA.

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Hiroaki Matsushita

2SAB Biotherapeutics Inc., Sioux Falls, SD 57104, USA.

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Ye Liu

6Novavax Inc., Gaithersburg, MD 20878, USA.

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Elena N. Postnikova

7Integrated Research Facility at Fort Detrick, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, MD 21702, USA.

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Britini L. Ork

7Integrated Research Facility at Fort Detrick, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, MD 21702, USA.

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Gregory Glenn

6Novavax Inc., Gaithersburg, MD 20878, USA.

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David Flyer

6Novavax Inc., Gaithersburg, MD 20878, USA.

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Gabriel Defang

8Department of Virology, Naval Medical Research Unit-3, Cairo FPO AP 09835, Egypt.

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Kanakatte Raviprakash

8Department of Virology, Naval Medical Research Unit-3, Cairo FPO AP 09835, Egypt.

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Tadeusz Kochel

9Viral and Rickettsial Diseases Department, Navy Medical Research Center, Silver Spring, MD 20910, USA.

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For correspondence: thomas.c.luke.ctr@mail.mil

Jonathan Wang

10Thermo Fisher Scientific, South San Francisco, CA 94080, USA.

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Wensheng Nie

10Thermo Fisher Scientific, South San Francisco, CA 94080, USA.

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Gale Smith

6Novavax Inc., Gaithersburg, MD 20878, USA.

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Lisa E. Hensley

7Integrated Research Facility at Fort Detrick, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, MD 21702, USA.

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Gene G. Olinger

7Integrated Research Facility at Fort Detrick, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, MD 21702, USA.

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Jens H. Kuhn

7Integrated Research Facility at Fort Detrick, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, MD 21702, USA.

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Michael R. Holbrook

7Integrated Research Facility at Fort Detrick, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, MD 21702, USA.

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Reed F. Johnson

11Emerging Viral Pathogens Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, MD 21702, USA.

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Stanley Perlman

3Department of Microbiology, University of Iowa, Iowa City, IA 52242, USA.

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Eddie Sullivan

2SAB Biotherapeutics Inc., Sioux Falls, SD 57104, USA.

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Matthew B. Frieman

5Department of Microbiology and Immunology, University of Maryland, School of Medicine, Baltimore, MD 21201, USA.

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Human polyclonal immunoglobulin G from transchromosomic bovines inhibits MERS-CoV in vivo

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