Research ArticleInfectious Disease

Human polyclonal immunoglobulin G from transchromosomic bovines inhibits MERS-CoV in vivo

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Science Translational Medicine  17 Feb 2016:
Vol. 8, Issue 326, pp. 326ra21
DOI: 10.1126/scitranslmed.aaf1061

Article Information

vol. 8 no. 326 326ra21

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication December 12, 2015
  • Accepted for publication January 14, 2016
  • .

Author Information

  1. Thomas Luke1,*,
  2. Hua Wu2,
  3. Jincun Zhao3,4,
  4. Rudragouda Channappanavar3,
  5. Christopher M. Coleman5,
  6. Jin-An Jiao2,
  7. Hiroaki Matsushita2,
  8. Ye Liu6,
  9. Elena N. Postnikova7,
  10. Britini L. Ork7,
  11. Gregory Glenn6,
  12. David Flyer6,
  13. Gabriel Defang8,
  14. Kanakatte Raviprakash9,
  15. Tadeusz Kochel9,,
  16. Jonathan Wang10,
  17. Wensheng Nie10,
  18. Gale Smith6,
  19. Lisa E. Hensley7,
  20. Gene G. Olinger7,
  21. Jens H. Kuhn7,
  22. Michael R. Holbrook7,
  23. Reed F. Johnson11,
  24. Stanley Perlman3,
  25. Eddie Sullivan2 and
  26. Matthew B. Frieman5
  1. 1Viral and Rickettsial Diseases Department, Navy Medical Research Center, The Henry Jackson Foundation for the Advancement of Military Medicine, Silver Spring, MD 20910, USA.
  2. 2SAB Biotherapeutics Inc., Sioux Falls, SD 57104, USA.
  3. 3Department of Microbiology, University of Iowa, Iowa City, IA 52242, USA.
  4. 4State Key Laboratory of Respiratory Diseases, Guangzhou Institute of Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510120, China.
  5. 5Department of Microbiology and Immunology, University of Maryland, School of Medicine, Baltimore, MD 21201, USA.
  6. 6Novavax Inc., Gaithersburg, MD 20878, USA.
  7. 7Integrated Research Facility at Fort Detrick, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, MD 21702, USA.
  8. 8Department of Virology, Naval Medical Research Unit-3, Cairo FPO AP 09835, Egypt.
  9. 9Viral and Rickettsial Diseases Department, Navy Medical Research Center, Silver Spring, MD 20910, USA.
  10. 10Thermo Fisher Scientific, South San Francisco, CA 94080, USA.
  11. 11Emerging Viral Pathogens Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, MD 21702, USA.
  1. *Corresponding author. E-mail: thomas.c.luke.ctr{at}mail.mil
    • Present address: Forensic Virology, National Biodefense Analysis and Countermeasures Center, Frederick, MD 21702, USA.

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