Research ArticleCancer

MM-151 overcomes acquired resistance to cetuximab and panitumumab in colorectal cancers harboring EGFR extracellular domain mutations

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Science Translational Medicine  03 Feb 2016:
Vol. 8, Issue 324, pp. 324ra14
DOI: 10.1126/scitranslmed.aad5640

Article Information

vol. 8 no. 324 324ra14

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication October 3, 2015
  • Accepted for publication January 8, 2016

Author Information

  1. Sabrina Arena1,2,3,*,
  2. Giulia Siravegna1,3,
  3. Benedetta Mussolin1,
  4. Jeffrey D. Kearns4,
  5. Beni B. Wolf4,,
  6. Sandra Misale1,,
  7. Luca Lazzari1,3,
  8. Andrea Bertotti1,3,
  9. Livio Trusolino1,3,
  10. Alex A. Adjei5,
  11. Clara Montagut6,7,
  12. Federica Di Nicolantonio1,3,
  13. Rachel Nering4 and
  14. Alberto Bardelli1,3,*
  1. 1Candiolo Cancer Institute–Fondazione del Piemonte per l'Oncologia (FPO), IRCCS, Candiolo, Torino 10060, Italy.
  2. 2FIRC Institute of Molecular Oncology (IFOM), Milano 20139, Italy.
  3. 3Department of Oncology, University of Torino, Candiolo, Torino 10060, Italy.
  4. 4Merrimack Pharmaceuticals Inc., Cambridge, MA 02139, USA.
  5. 5Roswell Park Cancer Institute, Buffalo, NY 14263, USA.
  6. 6Medical Oncology Department, Hospital del Mar, Barcelona 08003, Spain.
  7. 7Cancer Research Program, FIMIM (Hospital del Mar Medical Research Institute), Hospital del Mar, Barcelona 08003, Spain.
  1. *Corresponding author. E-mail: sabrina.arena{at}ircc.it (S.A.); alberto.bardelli{at}unito.it (A. Bardelli)
  • Present address: Blueprint Medicines, Cambridge, MA 02139, USA.

  • Present address: Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA 02129, USA.

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