Contents

Contents

• Perspective

  • Perspectives from man’s best friend: National Academy of Medicine’s Workshop on Comparative Oncology

    By Amy K. LeBlanc, Matthew Breen, Peter Choyke, Mark Dewhirst, Timothy M. Fan, Daniel L. Gustafson, Lee J. Helman, Michael B. Kastan, Deborah W. Knapp, Wendy J. Levin, Cheryl London, Nicola Mason, Christina Mazcko, Patricia N. Olson, Rodney Page, Beverly A. Teicher, Douglas H. Thamm, Jeffrey M. Trent, David M. Vail, Chand Khanna

    Science Translational Medicine03 Feb 2016 : 324ps5 Full AccessRestricted Access

    Scientists gather to survey comparative oncology research and pinpoint potential contributions to human therapeutics.

    • Abstract
    • Full Text
    • PDF

• Research Articles

  • MM-151 overcomes acquired resistance to cetuximab and panitumumab in colorectal cancers harboring EGFR extracellular domain mutations

    By Sabrina Arena, Giulia Siravegna, Benedetta Mussolin, Jeffrey D. Kearns, Beni B. Wolf, Sandra Misale, Luca Lazzari, Andrea Bertotti, Livio Trusolino, Alex A. Adjei, Clara Montagut, Federica Di Nicolantonio, Rachel Nering, Alberto Bardelli

    Science Translational Medicine03 Feb 2016 : 324ra14 Full AccessRestricted Access

    An oligoclonal antibody overcomes drug resistance in colorectal cancers with EGFR mutations.

    • Editor's Summary
    • Abstract
    • Full Text
    • PDF
    • Supplementary Materials

  • Mathematical modeling of herpes simplex virus-2 suppression with pritelivir predicts trial outcomes

    By Joshua T. Schiffer, David A. Swan, Amalia Magaret, Lawrence Corey, Anna Wald, Joachim Ossig, Helga Ruebsamen-Schaeff, Susanne Stoelben, Burkhard Timmler, Holger Zimmermann, Murad R. Melhem, Scott A. Van Wart, Christopher M. Rubino, Alexander Birkmann

    Science Translational Medicine03 Feb 2016 : 324ra15 Full AccessRestricted Access

    A mathematical model for antiviral clinical trials improves dose selection and understanding of drug-virus interaction.

    • Editor's Summary
    • Abstract
    • Full Text
    • PDF
    • Supplementary Materials

  • Timing of expression of the core clock gene Bmal1 influences its effects on aging and survival

    By Guangrui Yang, Lihong Chen, Gregory R. Grant, Georgios Paschos, Wen-Liang Song, Erik S. Musiek, Vivian Lee, Sarah C. McLoughlin, Tilo Grosser, George Cotsarelis, Garret A. FitzGerald

    Science Translational Medicine03 Feb 2016 : 324ra16 Full AccessRestricted Access

    Postnatal knockout of a core clock gene in mice prompts reevaluation of the systemic role of the molecular clock in the biology of aging.

    • Editor's Summary
    • Abstract
    • Full Text
    • PDF
    • Supplementary Materials

• Editors' Choice

  • A notch against cancer

    By Ellen J. Beswick

    Science Translational Medicine03 Feb 2016 : 324ec17 Full AccessRestricted Access

    Notch signaling may be antitumorigenic in some cancers.

    • Full Text

  • Blocking Borrelia in the brain

    By Christopher G. Janson

    Science Translational Medicine03 Feb 2016 : 324ec18 Full AccessRestricted Access

    Neurokinin-1 receptor blockade inhibits neuroinflammation and apoptosis in a nonhuman primate model of Borrelia infection.

    • Full Text

  • Aging metabolism: Evitable or inevitable?

    By Ian R. Lanza

    Science Translational Medicine03 Feb 2016 : 324ec19 Full AccessRestricted Access

    Lifestyle factors can explain many, but not all, of aging-related metabolic disturbances.

    • Full Text

  • Relative immunity

    By Anne Marie Singh

    Science Translational Medicine03 Feb 2016 : 324ec20 Full AccessRestricted Access

    Siblings enhance immune responses in the airway of asymptomatic neonates, an effect that may modify asthma risk.

    • Full Text

  • The mRNA “game changer” in gene therapy

    By Andrew Z. Wang

    Science Translational Medicine03 Feb 2016 : 324ec21 Full AccessRestricted Access

    A new type of nanomaterial can deliver siRNA and mRNA in vivo with high efficiency and low toxicity.

    • Full Text

• Erratum

  • Erratum for the Research Article: “RANKL blockade prevents and treats aggressive osteosarcomas” by Y. Chen, M. A. Di Grappa, S. D. Molyneux, T. D. McKee, P. Waterhouse, J. M. Penninger, R. Khokha

    Science Translational Medicine03 Feb 2016 : 324er2 Full AccessRestricted Access

    • Full Text