Contents
Vol 8, Issue 324
Contents
Perspective
- Perspectives from man’s best friend: National Academy of Medicine’s Workshop on Comparative Oncology
Scientists gather to survey comparative oncology research and pinpoint potential contributions to human therapeutics.
Research Articles
- MM-151 overcomes acquired resistance to cetuximab and panitumumab in colorectal cancers harboring EGFR extracellular domain mutations
An oligoclonal antibody overcomes drug resistance in colorectal cancers with EGFR mutations.
- Mathematical modeling of herpes simplex virus-2 suppression with pritelivir predicts trial outcomes
A mathematical model for antiviral clinical trials improves dose selection and understanding of drug-virus interaction.
- Timing of expression of the core clock gene Bmal1 influences its effects on aging and survival
Postnatal knockout of a core clock gene in mice prompts reevaluation of the systemic role of the molecular clock in the biology of aging.
Editors' Choice
- Blocking Borrelia in the brain
Neurokinin-1 receptor blockade inhibits neuroinflammation and apoptosis in a nonhuman primate model of Borrelia infection.
- Aging metabolism: Evitable or inevitable?
Lifestyle factors can explain many, but not all, of aging-related metabolic disturbances.
- Relative immunity
Siblings enhance immune responses in the airway of asymptomatic neonates, an effect that may modify asthma risk.
- The mRNA “game changer” in gene therapy
A new type of nanomaterial can deliver siRNA and mRNA in vivo with high efficiency and low toxicity.
Erratum
About The Cover

ONLINE COVER Dosing HSV. A transmission electron micrograph of herpes simplex virus. Schiffer et al. develop a mathematical model for HSV antiviral clinical trials that improves dose selection and understanding of drug-virus interactions. [CREDIT: JAMES CAVALLINI/SCIENCE SOURCE]