Research ArticleOBESITY AND METABOLISM

USF1 deficiency activates brown adipose tissue and improves cardiometabolic health

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Science Translational Medicine  27 Jan 2016:
Vol. 8, Issue 323, pp. 323ra13
DOI: 10.1126/scitranslmed.aad0015

Article Information

vol. 8 no. 323 323ra13

PubMed: 
Print ISSN: 
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History: 
  • Received for publication July 17, 2015
  • Accepted for publication January 8, 2016
  • .

Author Information

  1. Pirkka-Pekka Laurila1,2,3,*,,
  2. Jarkko Soronen1,3,4,*,
  3. Sander Kooijman5,6,
  4. Saara Forsström7,
  5. Mariëtte R. Boon5,6,
  6. Ida Surakka1,3,
  7. Essi Kaiharju1,
  8. Claudia P. Coomans5,8,
  9. Sjoerd A. A. Van Den Berg9,
  10. Anu Autio10,
  11. Antti-Pekka Sarin1,3,
  12. Johannes Kettunen1,3,11,
  13. Emmi Tikkanen1,3,12,
  14. Tuula Manninen1,7,
  15. Jari Metso1,
  16. Reija Silvennoinen13,
  17. Krista Merikanto1,
  18. Maija Ruuth13,
  19. Julia Perttilä4,
  20. Anne Mäkelä14,
  21. Ayaka Isomi15,
  22. Anita M. Tuomainen16,
  23. Anna Tikka1,
  24. Usama Abo Ramadan17,
  25. Ilkka Seppälä18,
  26. Terho Lehtimäki18,
  27. Johan Eriksson19,20,21,22,
  28. Aki Havulinna19,
  29. Antti Jula19,
  30. Pekka J. Karhunen18,
  31. Veikko Salomaa19,
  32. Markus Perola1,
  33. Christian Ehnholm1,
  34. Miriam Lee-Rueckert13,
  35. Miranda Van Eck5,
  36. Anne Roivainen10,23,
  37. Marja-Riitta Taskinen24,
  38. Leena Peltonen,
  39. Eero Mervaala25,
  40. Anu Jalanko1,
  41. Esa Hohtola26,
  42. Vesa M. Olkkonen4,
  43. Samuli Ripatti1,3,12,27,
  44. Petri T. Kovanen13,
  45. Patrick C. N. Rensen5,6,
  46. Anu Suomalainen7,28,29 and
  47. Matti Jauhiainen1,
  1. 1Genomics and Biomarkers Unit, National Institute for Health and Welfare, Helsinki FI-00251, Finland.
  2. 2Department of Medical Genetics, University of Helsinki, Helsinki FI-00014, Finland.
  3. 3Institute for Molecular Medicine Finland, FIMM, Helsinki FI-00251, Finland.
  4. 4Minerva Foundation Institute for Medical Research, Helsinki FI-00290, Finland.
  5. 5Department of Endocrinology and Metabolic Diseases, Leiden University Medical Center, Leiden 2333 ZA, Netherlands.
  6. 6Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden 2333 ZA, Netherlands.
  7. 7Molecular Neurology, Research Programs Unit, University of Helsinki, Helsinki FI-00014, Finland.
  8. 8Department of Molecular Cell Biology, Leiden University Medical Center, Leiden 2333 ZA, Netherlands.
  9. 9Department of Human Genetics, Leiden University Medical Center, Leiden 2333 ZA, Netherlands.
  10. 10Turku PET Centre, University of Turku and Turku University Hospital, Turku FI-20520, Finland.
  11. 11Computational Medicine, Institute of Health Sciences, University of Oulu and Oulu University Hospital, Oulu FI-90014, Finland.
  12. 12Hjelt Institute, University of Helsinki, Helsinki FI-00014, Finland.
  13. 13Wihuri Research Institute, Helsinki FI-00290, Finland.
  14. 14Faculty of Biochemistry and Molecular Medicine, University of Oulu, Oulu FI-90014, Finland.
  15. 15Hiroshima University, Hiroshima 730-0053, Japan.
  16. 16Institute of Dentistry, University of Helsinki, Helsinki FI-00014, Finland.
  17. 17Experimental MRI Laboratory, Department of Neurology, Helsinki University Central Hospital, Helsinki FI-00290, Finland.
  18. 18Department of Clinical Chemistry, Fimlab Laboratories, and Tampere University School of Medicine, Tampere FI-33014, Finland.
  19. 19Department of Health, National Institute for Health and Welfare, Helsinki FI-00271, Finland.
  20. 20Folkhälsan Research Centre, Helsinki FI-00251, Finland.
  21. 21Unit of General Practice, Helsinki University Central Hospital, Helsinki FI-00290, Finland.
  22. 22Department of General Practice and Primary Health Care, University of Helsinki, Helsinki FI-00014, Finland.
  23. 23Turku Center for Disease Modeling, University of Turku, Turku FI-20520, Finland.
  24. 24Diabetes and Obesity Research Program, University of Helsinki, Helsinki FI-00014, Finland.
  25. 25Institute of Biomedicine, University of Helsinki, Helsinki FI-00014, Finland.
  26. 26Department of Genetics and Physiology, University of Oulu, Oulu FI-90014, Finland.
  27. 27Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK.
  28. 28Department of Neurology, Helsinki University Central Hospital, Helsinki FI-00290, Finland.
  29. 29Neuroscience Center, University of Helsinki, Helsinki FI-00014, Finland.
  1. Corresponding author. E-mail: pirkka-pekka.laurila{at}thl.fi (P.-P.L.); matti.jauhiainen{at}thl.fi (M.J.)
  • * These authors had a main contribution to this work.

  • Deceased.

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