Research ArticleOBESITY AND METABOLISM

USF1 deficiency activates brown adipose tissue and improves cardiometabolic health

See allHide authors and affiliations

Science Translational Medicine  27 Jan 2016:
Vol. 8, Issue 323, pp. 323ra13
DOI: 10.1126/scitranslmed.aad0015

You are currently viewing the editor's summary.

View Full Text

Log in to view the full text

Log in through your institution

Log in through your institution

Boosting metabolism with low USF1

Laurila et al. show that a deficiency of the transcription factor USF1 protects against obesity, insulin resistance, and cardiovascular disease. Even when fed a high-fat diet, USF1-deficient mice stayed lean and maintained a beneficial lipid profile with low triglycerides and high high-density lipoprotein (HDL) cholesterol. The mice had elevated energy expenditure because their brown adipose tissue was more active. In USF1-deficient mice, glucose and lipids were rapidly cleared from the circulation to be burned by brown fat. In humans, individuals with reduced USF1 expression also had higher plasma HDL cholesterol and lower triglycerides, and were more insulin-sensitive and less prone to hardening of the arteries. These findings identify USF1 as a potential therapeutic target for treating metabolic and cardiac diseases.

View Full Text

Stay Connected to Science Translational Medicine