Complex effects of inhibiting hepatic apolipoprotein B100 synthesis in humans

Gissette Reyes-Soffer; Byoung Moon; Antonio Hernandez-Ono; Marija Dionizovik-Dimanovski; Jhonsua Jimenez; Joseph Obunike; Tiffany Thomas; Colleen Ngai; Nelson Fontanez; Daniel S. Donovan; Wahida Karmally; Stephen Holleran; Rajasekhar Ramakrishnan; Robert S. Mittleman; Henry N. Ginsberg

doi:10.1126/scitranslmed.aad2195

Research ArticleMetabolism

Complex effects of inhibiting hepatic apolipoprotein B100 synthesis in humans

Gissette Reyes-Soffer¹,*,
Byoung Moon¹,
Antonio Hernandez-Ono¹,
Marija Dionizovik-Dimanovski¹,
Jhonsua Jimenez¹,
Joseph Obunike²,
Tiffany Thomas¹,
Colleen Ngai¹,
Nelson Fontanez¹,
Daniel S. Donovan¹,
Wahida Karmally¹,
Stephen Holleran¹,
Rajasekhar Ramakrishnan¹,
Robert S. Mittleman³ † and
Henry N. Ginsberg¹,*

¹Columbia University College of Physicians and Surgeons, 630 West 168th Street, New York, NY 10032, USA.
²Biological Sciences Department, New York City College of Technology, 300 Jay Street, Brooklyn, NY 11201, USA.
³Sanofi-Genzyme, 500 Kendall Street, Cambridge, MA 02142, USA.

↵*Corresponding author. E-mail: gr2104{at}cumc.columbia.edu (G.R.-S.); hng1{at}cumc.columbia.edu (H.N.G.)

↵† Present address: Ironwood Pharmaceuticals, 301 Binney Street, Cambridge, MA 02142, USA.

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Science Translational Medicine 27 Jan 2016:
Vol. 8, Issue 323, pp. 323ra12
DOI: 10.1126/scitranslmed.aad2195

Gissette Reyes-Soffer

1Columbia University College of Physicians and Surgeons, 630 West 168th Street, New York, NY 10032, USA.

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For correspondence: gr2104@cumc.columbia.edu hng1@cumc.columbia.edu

Byoung Moon

1Columbia University College of Physicians and Surgeons, 630 West 168th Street, New York, NY 10032, USA.

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Antonio Hernandez-Ono

1Columbia University College of Physicians and Surgeons, 630 West 168th Street, New York, NY 10032, USA.

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Marija Dionizovik-Dimanovski

1Columbia University College of Physicians and Surgeons, 630 West 168th Street, New York, NY 10032, USA.

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Jhonsua Jimenez

1Columbia University College of Physicians and Surgeons, 630 West 168th Street, New York, NY 10032, USA.

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Joseph Obunike

2Biological Sciences Department, New York City College of Technology, 300 Jay Street, Brooklyn, NY 11201, USA.

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Tiffany Thomas

1Columbia University College of Physicians and Surgeons, 630 West 168th Street, New York, NY 10032, USA.

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Colleen Ngai

1Columbia University College of Physicians and Surgeons, 630 West 168th Street, New York, NY 10032, USA.

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Nelson Fontanez

1Columbia University College of Physicians and Surgeons, 630 West 168th Street, New York, NY 10032, USA.

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Daniel S. Donovan

1Columbia University College of Physicians and Surgeons, 630 West 168th Street, New York, NY 10032, USA.

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Wahida Karmally

1Columbia University College of Physicians and Surgeons, 630 West 168th Street, New York, NY 10032, USA.

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Stephen Holleran

1Columbia University College of Physicians and Surgeons, 630 West 168th Street, New York, NY 10032, USA.

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Rajasekhar Ramakrishnan

1Columbia University College of Physicians and Surgeons, 630 West 168th Street, New York, NY 10032, USA.

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Robert S. Mittleman

3Sanofi-Genzyme, 500 Kendall Street, Cambridge, MA 02142, USA.

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Henry N. Ginsberg

1Columbia University College of Physicians and Surgeons, 630 West 168th Street, New York, NY 10032, USA.

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For correspondence: gr2104@cumc.columbia.edu hng1@cumc.columbia.edu

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Targeting apoB synthesis with mipomersen (KYNAMRO) can be effective for lowering plasma levels of apoB lipoproteins without reducing the secretion of VLDL.

Complex effects of inhibiting hepatic apolipoprotein B100 synthesis in humans

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