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Research ArticleMetabolism
Complex effects of inhibiting hepatic apolipoprotein B100 synthesis in humans
- Gissette Reyes-Soffer1,*,
- Byoung Moon1,
- Antonio Hernandez-Ono1,
- Marija Dionizovik-Dimanovski1,
- Jhonsua Jimenez1,
- Joseph Obunike2,
- Tiffany Thomas1,
- Colleen Ngai1,
- Nelson Fontanez1,
- Daniel S. Donovan1,
- Wahida Karmally1,
- Stephen Holleran1,
- Rajasekhar Ramakrishnan1,
- Robert S. Mittleman3† and
- Henry N. Ginsberg1,*
- 1Columbia University College of Physicians and Surgeons, 630 West 168th Street, New York, NY 10032, USA.
- 2Biological Sciences Department, New York City College of Technology, 300 Jay Street, Brooklyn, NY 11201, USA.
- 3Sanofi-Genzyme, 500 Kendall Street, Cambridge, MA 02142, USA.
- ↵*Corresponding author. E-mail: gr2104{at}cumc.columbia.edu (G.R.-S.); hng1{at}cumc.columbia.edu (H.N.G.)
↵† Present address: Ironwood Pharmaceuticals, 301 Binney Street, Cambridge, MA 02142, USA.
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Science Translational Medicine 27 Jan 2016:
Vol. 8, Issue 323, pp. 323ra12
DOI: 10.1126/scitranslmed.aad2195
Vol. 8, Issue 323, pp. 323ra12
DOI: 10.1126/scitranslmed.aad2195
Gissette Reyes-Soffer
1Columbia University College of Physicians and Surgeons, 630 West 168th Street, New York, NY 10032, USA.
Byoung Moon
1Columbia University College of Physicians and Surgeons, 630 West 168th Street, New York, NY 10032, USA.
Antonio Hernandez-Ono
1Columbia University College of Physicians and Surgeons, 630 West 168th Street, New York, NY 10032, USA.
Marija Dionizovik-Dimanovski
1Columbia University College of Physicians and Surgeons, 630 West 168th Street, New York, NY 10032, USA.
Jhonsua Jimenez
1Columbia University College of Physicians and Surgeons, 630 West 168th Street, New York, NY 10032, USA.
Joseph Obunike
2Biological Sciences Department, New York City College of Technology, 300 Jay Street, Brooklyn, NY 11201, USA.
Tiffany Thomas
1Columbia University College of Physicians and Surgeons, 630 West 168th Street, New York, NY 10032, USA.
Colleen Ngai
1Columbia University College of Physicians and Surgeons, 630 West 168th Street, New York, NY 10032, USA.
Nelson Fontanez
1Columbia University College of Physicians and Surgeons, 630 West 168th Street, New York, NY 10032, USA.
Daniel S. Donovan
1Columbia University College of Physicians and Surgeons, 630 West 168th Street, New York, NY 10032, USA.
Wahida Karmally
1Columbia University College of Physicians and Surgeons, 630 West 168th Street, New York, NY 10032, USA.
Stephen Holleran
1Columbia University College of Physicians and Surgeons, 630 West 168th Street, New York, NY 10032, USA.
Rajasekhar Ramakrishnan
1Columbia University College of Physicians and Surgeons, 630 West 168th Street, New York, NY 10032, USA.
Robert S. Mittleman
3Sanofi-Genzyme, 500 Kendall Street, Cambridge, MA 02142, USA.
Henry N. Ginsberg
1Columbia University College of Physicians and Surgeons, 630 West 168th Street, New York, NY 10032, USA.
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