PerspectiveMetabolic Disease

Hyaluronan in adipose tissue: Beyond dermal filler and therapeutic carrier

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Science Translational Medicine  27 Jan 2016:
Vol. 8, Issue 323, pp. 323ps4
DOI: 10.1126/scitranslmed.aad6793


  • Fig. 1. Illustration depicting an adipocyte and its extracellular matrix focusing on hyaluronic acid.

    Collagen I fibrils form the main structural component and provide the physical support of the adipose tissue. Collagen VI is the major isoform of collagen that surrounds each adipocyte. HAs are synthesized by HAS2 and exported during the synthesis. HA fibrils provide an anchor for the proteoglycan core protein aggrecan. HYAL2 processes HAs into small fragments, which have a different binding dynamics compared with high-molecular-weight HA, and may promote angiogenesis and attract macrophages, eosinophils, and other cells.

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