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Research ArticleInfectious Disease
Host gene expression classifiers diagnose acute respiratory illness etiology
- Ephraim L. Tsalik1,2,3,*,
- Ricardo Henao1,4,*,
- Marshall Nichols1,
- Thomas Burke1,
- Emily R. Ko1,5,
- Micah T. McClain1,3,6,
- Lori L. Hudson1,
- Anna Mazur1,
- Debra H. Freeman1,3,
- Tim Veldman1,
- Raymond J. Langley7,
- Eugenia B. Quackenbush8,
- Seth W. Glickman8,
- Charles B. Cairns8,9,
- Anja K. Jaehne10,
- Emanuel P. Rivers10,
- Ronny M. Otero10,
- Aimee K. Zaas1,3,
- Stephen F. Kingsmore11,
- Joseph Lucas1,
- Vance G. Fowler Jr3,
- Lawrence Carin1,4,
- Geoffrey S. Ginsburg1,† and
- Christopher W. Woods1,3,6,†
- 1Center for Applied Genomics and Precision Medicine, Department of Medicine, Duke University, Durham, NC 27708, USA.
- 2Emergency Medicine Service, Durham Veteran’s Affairs Medical Center, Durham, NC 27705, USA.
- 3Division of Infectious Diseases and International Health, Department of Medicine, Duke University, Durham, NC 27710, USA.
- 4Department of Electrical and Computer Engineering, Duke University, Durham, NC 27708, USA.
- 5Duke Regional Hospital, Department of Medicine, Duke University, Durham, NC 27710, USA.
- 6Section for Infectious Diseases, Medicine Service, Durham Veteran’s Affairs Medical Center, Durham, NC 27705, USA.
- 7Immunology Division, Lovelace Respiratory Research Institute, Albuquerque, NM 87108, USA.
- 8Department of Emergency Medicine, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA.
- 9Department of Emergency Medicine, University of Arizona Health Sciences Center, Tucson, AZ 85724, USA.
- 10Department of Emergency Medicine, Henry Ford Hospital, Wayne State University, Detroit, MI 48202, USA.
- 11Rady Pediatric Genomic and Systems Medicine Institute, Rady Children’s Hospital, San Diego, CA 92123, USA.
- ↵†Corresponding author. E-mail: geoffrey.ginsburg{at}duke.edu (G.S.G.); chris.woods{at}duke.edu (C.W.W.)
↵* These authors contributed equally to this work.
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Science Translational Medicine 20 Jan 2016:
Vol. 8, Issue 322, pp. 322ra11
DOI: 10.1126/scitranslmed.aad6873
Vol. 8, Issue 322, pp. 322ra11
DOI: 10.1126/scitranslmed.aad6873
Ephraim L. Tsalik
1Center for Applied Genomics and Precision Medicine, Department of Medicine, Duke University, Durham, NC 27708, USA.
2Emergency Medicine Service, Durham Veteran’s Affairs Medical Center, Durham, NC 27705, USA.
3Division of Infectious Diseases and International Health, Department of Medicine, Duke University, Durham, NC 27710, USA.
Ricardo Henao
1Center for Applied Genomics and Precision Medicine, Department of Medicine, Duke University, Durham, NC 27708, USA.
4Department of Electrical and Computer Engineering, Duke University, Durham, NC 27708, USA.
Marshall Nichols
1Center for Applied Genomics and Precision Medicine, Department of Medicine, Duke University, Durham, NC 27708, USA.
Thomas Burke
1Center for Applied Genomics and Precision Medicine, Department of Medicine, Duke University, Durham, NC 27708, USA.
Emily R. Ko
1Center for Applied Genomics and Precision Medicine, Department of Medicine, Duke University, Durham, NC 27708, USA.
5Duke Regional Hospital, Department of Medicine, Duke University, Durham, NC 27710, USA.
Micah T. McClain
1Center for Applied Genomics and Precision Medicine, Department of Medicine, Duke University, Durham, NC 27708, USA.
3Division of Infectious Diseases and International Health, Department of Medicine, Duke University, Durham, NC 27710, USA.
6Section for Infectious Diseases, Medicine Service, Durham Veteran’s Affairs Medical Center, Durham, NC 27705, USA.
Lori L. Hudson
1Center for Applied Genomics and Precision Medicine, Department of Medicine, Duke University, Durham, NC 27708, USA.
Anna Mazur
1Center for Applied Genomics and Precision Medicine, Department of Medicine, Duke University, Durham, NC 27708, USA.
Debra H. Freeman
1Center for Applied Genomics and Precision Medicine, Department of Medicine, Duke University, Durham, NC 27708, USA.
3Division of Infectious Diseases and International Health, Department of Medicine, Duke University, Durham, NC 27710, USA.
Tim Veldman
1Center for Applied Genomics and Precision Medicine, Department of Medicine, Duke University, Durham, NC 27708, USA.
Raymond J. Langley
7Immunology Division, Lovelace Respiratory Research Institute, Albuquerque, NM 87108, USA.
Eugenia B. Quackenbush
8Department of Emergency Medicine, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA.
Seth W. Glickman
8Department of Emergency Medicine, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA.
Charles B. Cairns
8Department of Emergency Medicine, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA.
9Department of Emergency Medicine, University of Arizona Health Sciences Center, Tucson, AZ 85724, USA.
Anja K. Jaehne
10Department of Emergency Medicine, Henry Ford Hospital, Wayne State University, Detroit, MI 48202, USA.
Emanuel P. Rivers
10Department of Emergency Medicine, Henry Ford Hospital, Wayne State University, Detroit, MI 48202, USA.
Ronny M. Otero
10Department of Emergency Medicine, Henry Ford Hospital, Wayne State University, Detroit, MI 48202, USA.
Aimee K. Zaas
1Center for Applied Genomics and Precision Medicine, Department of Medicine, Duke University, Durham, NC 27708, USA.
3Division of Infectious Diseases and International Health, Department of Medicine, Duke University, Durham, NC 27710, USA.
Stephen F. Kingsmore
11Rady Pediatric Genomic and Systems Medicine Institute, Rady Children’s Hospital, San Diego, CA 92123, USA.
Joseph Lucas
1Center for Applied Genomics and Precision Medicine, Department of Medicine, Duke University, Durham, NC 27708, USA.
Vance G. Fowler Jr
3Division of Infectious Diseases and International Health, Department of Medicine, Duke University, Durham, NC 27710, USA.
Lawrence Carin
1Center for Applied Genomics and Precision Medicine, Department of Medicine, Duke University, Durham, NC 27708, USA.
4Department of Electrical and Computer Engineering, Duke University, Durham, NC 27708, USA.
Geoffrey S. Ginsburg
1Center for Applied Genomics and Precision Medicine, Department of Medicine, Duke University, Durham, NC 27708, USA.
Christopher W. Woods
1Center for Applied Genomics and Precision Medicine, Department of Medicine, Duke University, Durham, NC 27708, USA.
3Division of Infectious Diseases and International Health, Department of Medicine, Duke University, Durham, NC 27710, USA.
6Section for Infectious Diseases, Medicine Service, Durham Veteran’s Affairs Medical Center, Durham, NC 27705, USA.
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