Research ArticleInfectious Disease

CXCR1-mediated neutrophil degranulation and fungal killing promote Candida clearance and host survival

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Science Translational Medicine  20 Jan 2016:
Vol. 8, Issue 322, pp. 322ra10
DOI: 10.1126/scitranslmed.aac7718

Candida camera

The yeast Candida albicans can live symbiotically in human gut and skin, but when it penetrates the mucosal barrier and enters the bloodstream, it can cause life-threatening systemic infection. Now, Swamydas et al. provide a look at how neutrophils control Candida. They show that the neutrophil-selective chemokine receptor Cxcr1 plays a critical role in antifungal host defense. Mice lacking Cxcr1 were more susceptible to systemic candidiasis because of defective neutrophil-mediated fungal killing. Neutrophils from humans with a mutant CXCR1 allele also had defective fungal response. These data suggest that Cxcr1 is critical for innate host defense against fungal infection.