Research ArticleImmunodeficiency
Inhibition of diacylglycerol kinase α restores restimulation-induced cell death and reduces immunopathology in XLP-1
- Elisa Ruffo1,*,
- Valeria Malacarne1,*,
- Sasha E. Larsen2,*,
- Rupali Das3,*,
- Laura Patrussi4,
- Christoph Wülfing5,
- Christoph Biskup6,
- Senta M. Kapnick7,
- Katherine Verbist8,
- Paige Tedrick8,
- Pamela L. Schwartzberg7,
- Cosima T. Baldari4,
- Ignacio Rubio9,
- Kim E. Nichols8,†,
- Andrew L. Snow2,†,
- Gianluca Baldanzi1,† and
- Andrea Graziani1,10,†,‡
- 1Department of Translational Medicine and Institute for Research and Cure of Autoimmune Diseases, University of Piemonte Orientale, 28100 Novara, Italy.
- 2Department of Pharmacology and Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA.
- 3Department of Physiology, Michigan State University, East Lansing, MI 48824, USA.
- 4Department of Life Sciences, University of Siena, 53100 Siena, Italy.
- 5School of Cellular and Molecular Medicine, University of Bristol, BS8 1TH Bristol, UK.
- 6Biomolecular Photonics Group, Jena University Hospital, D 07740 Jena, Germany.
- 7Genetic Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA.
- 8Department of Oncology, St. Jude Children’s Research Hospital, Memphis, TN 38105, USA.
- 9Integrated Research and Treatment Center, Center for Sepsis Control and Care and Institute of Molecular Cell Biology, Center for Molecular Biomedicine, Jena University Hospital, D-07745 Jena, Germany.
- 10School of Medicine, University Vita e Salute San Raffaele, 20132 Milan, Italy.
- ↵‡Corresponding author. E-mail: graziani.andrea{at}hsr.it
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Science Translational Medicine 13 Jan 2016:
Vol. 8, Issue 321, pp. 321ra7
DOI: 10.1126/scitranslmed.aad1565
