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Research ArticleImmunodeficiency
Inhibition of diacylglycerol kinase α restores restimulation-induced cell death and reduces immunopathology in XLP-1
- Elisa Ruffo1,*,
- Valeria Malacarne1,*,
- Sasha E. Larsen2,*,
- Rupali Das3,*,
- Laura Patrussi4,
- Christoph Wülfing5,
- Christoph Biskup6,
- Senta M. Kapnick7,
- Katherine Verbist8,
- Paige Tedrick8,
- Pamela L. Schwartzberg7,
- Cosima T. Baldari4,
- Ignacio Rubio9,
- Kim E. Nichols8,†,
- Andrew L. Snow2,†,
- Gianluca Baldanzi1,† and
- Andrea Graziani1,10,†,‡
- 1Department of Translational Medicine and Institute for Research and Cure of Autoimmune Diseases, University of Piemonte Orientale, 28100 Novara, Italy.
- 2Department of Pharmacology and Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA.
- 3Department of Physiology, Michigan State University, East Lansing, MI 48824, USA.
- 4Department of Life Sciences, University of Siena, 53100 Siena, Italy.
- 5School of Cellular and Molecular Medicine, University of Bristol, BS8 1TH Bristol, UK.
- 6Biomolecular Photonics Group, Jena University Hospital, D 07740 Jena, Germany.
- 7Genetic Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA.
- 8Department of Oncology, St. Jude Children’s Research Hospital, Memphis, TN 38105, USA.
- 9Integrated Research and Treatment Center, Center for Sepsis Control and Care and Institute of Molecular Cell Biology, Center for Molecular Biomedicine, Jena University Hospital, D-07745 Jena, Germany.
- 10School of Medicine, University Vita e Salute San Raffaele, 20132 Milan, Italy.
- ↵‡Corresponding author. E-mail: graziani.andrea{at}hsr.it
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Science Translational Medicine 13 Jan 2016:
Vol. 8, Issue 321, pp. 321ra7
DOI: 10.1126/scitranslmed.aad1565
Vol. 8, Issue 321, pp. 321ra7
DOI: 10.1126/scitranslmed.aad1565
Elisa Ruffo
1Department of Translational Medicine and Institute for Research and Cure of Autoimmune Diseases, University of Piemonte Orientale, 28100 Novara, Italy.
Valeria Malacarne
1Department of Translational Medicine and Institute for Research and Cure of Autoimmune Diseases, University of Piemonte Orientale, 28100 Novara, Italy.
Sasha E. Larsen
2Department of Pharmacology and Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA.
Rupali Das
3Department of Physiology, Michigan State University, East Lansing, MI 48824, USA.
Laura Patrussi
4Department of Life Sciences, University of Siena, 53100 Siena, Italy.
Christoph Wülfing
5School of Cellular and Molecular Medicine, University of Bristol, BS8 1TH Bristol, UK.
Christoph Biskup
6Biomolecular Photonics Group, Jena University Hospital, D 07740 Jena, Germany.
Senta M. Kapnick
7Genetic Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Katherine Verbist
8Department of Oncology, St. Jude Children’s Research Hospital, Memphis, TN 38105, USA.
Paige Tedrick
8Department of Oncology, St. Jude Children’s Research Hospital, Memphis, TN 38105, USA.
Pamela L. Schwartzberg
7Genetic Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Cosima T. Baldari
4Department of Life Sciences, University of Siena, 53100 Siena, Italy.
Ignacio Rubio
9Integrated Research and Treatment Center, Center for Sepsis Control and Care and Institute of Molecular Cell Biology, Center for Molecular Biomedicine, Jena University Hospital, D-07745 Jena, Germany.
Kim E. Nichols
8Department of Oncology, St. Jude Children’s Research Hospital, Memphis, TN 38105, USA.
Andrew L. Snow
2Department of Pharmacology and Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA.
Gianluca Baldanzi
1Department of Translational Medicine and Institute for Research and Cure of Autoimmune Diseases, University of Piemonte Orientale, 28100 Novara, Italy.
Andrea Graziani
1Department of Translational Medicine and Institute for Research and Cure of Autoimmune Diseases, University of Piemonte Orientale, 28100 Novara, Italy.
10School of Medicine, University Vita e Salute San Raffaele, 20132 Milan, Italy.
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