Research ArticleImmunodeficiency

Inhibition of diacylglycerol kinase α restores restimulation-induced cell death and reduces immunopathology in XLP-1

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Science Translational Medicine  13 Jan 2016:
Vol. 8, Issue 321, pp. 321ra7
DOI: 10.1126/scitranslmed.aad1565

Article Information

vol. 8 no. 321 321ra7

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication August 4, 2015
  • Accepted for publication December 3, 2015
  • .

Author Information

  1. Elisa Ruffo1,*,
  2. Valeria Malacarne1,*,
  3. Sasha E. Larsen2,*,
  4. Rupali Das3,*,
  5. Laura Patrussi4,
  6. Christoph Wülfing5,
  7. Christoph Biskup6,
  8. Senta M. Kapnick7,
  9. Katherine Verbist8,
  10. Paige Tedrick8,
  11. Pamela L. Schwartzberg7,
  12. Cosima T. Baldari4,
  13. Ignacio Rubio9,
  14. Kim E. Nichols8,,
  15. Andrew L. Snow2,,
  16. Gianluca Baldanzi1, and
  17. Andrea Graziani1,10,,
  1. 1Department of Translational Medicine and Institute for Research and Cure of Autoimmune Diseases, University of Piemonte Orientale, 28100 Novara, Italy.
  2. 2Department of Pharmacology and Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA.
  3. 3Department of Physiology, Michigan State University, East Lansing, MI 48824, USA.
  4. 4Department of Life Sciences, University of Siena, 53100 Siena, Italy.
  5. 5School of Cellular and Molecular Medicine, University of Bristol, BS8 1TH Bristol, UK.
  6. 6Biomolecular Photonics Group, Jena University Hospital, D 07740 Jena, Germany.
  7. 7Genetic Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA.
  8. 8Department of Oncology, St. Jude Children’s Research Hospital, Memphis, TN 38105, USA.
  9. 9Integrated Research and Treatment Center, Center for Sepsis Control and Care and Institute of Molecular Cell Biology, Center for Molecular Biomedicine, Jena University Hospital, D-07745 Jena, Germany.
  10. 10School of Medicine, University Vita e Salute San Raffaele, 20132 Milan, Italy.
  1. Corresponding author. E-mail: graziani.andrea{at}hsr.it
    • * These authors contributed equally to this work.

    • These authors contributed equally to this work.

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