Research ArticleTraumatic Brain Injury

Repetitive blast exposure in mice and combat veterans causes persistent cerebellar dysfunction

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Science Translational Medicine  13 Jan 2016:
Vol. 8, Issue 321, pp. 321ra6
DOI: 10.1126/scitranslmed.aaa9585

The cerebellum is vulnerable to blast injury in mice and combat veterans

Mild traumatic brain injury (TBI) is often referred to as the “signature injury” of the wars in Iraq and Afghanistan. Most of these TBIs are blast-related. Currently, there is limited understanding of how mild blast causes persistent brain injuries. There is also limited insight into how blast-induced brain injuries in animal models correspond to humans with mild TBI. Meabon et al. report that the cerebellum, a brain structure important for integrating sensory information and movement, is injured by blast exposure in mice in specific areas that correspond to abnormal brain imaging findings obtained in similar cerebellar regions in blast-exposed combat veterans.

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