Research ArticleCancer Imaging

A mouse-human phase 1 co-clinical trial of a protease-activated fluorescent probe for imaging cancer

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Science Translational Medicine  06 Jan 2016:
Vol. 8, Issue 320, pp. 320ra4
DOI: 10.1126/scitranslmed.aad0293

Article Information

vol. 8 no. 320 320ra4

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication July 15, 2015
  • Accepted for publication November 11, 2015
  • .

Author Information

  1. Melodi Javid Whitley1,2,
  2. Diana M. Cardona3,
  3. Alexander L. Lazarides4,
  4. Ivan Spasojevic5,6,
  5. Jorge M. Ferrer7,
  6. Joan Cahill8,
  7. Chang-Lung Lee8,
  8. Matija Snuderl9,*,
  9. Dan G. Blazer III10,
  10. E. Shelley Hwang10,
  11. Rachel A. Greenup10,
  12. Paul J. Mosca10,
  13. Jeffrey K. Mito1,2,
  14. Kyle C. Cuneo8,
  15. Nicole A. Larrier8,
  16. Erin K. O’Reilly11,
  17. Richard F. Riedel5,
  18. William C. Eward12,
  19. David B. Strasfeld7,
  20. Dai Fukumura9,
  21. Rakesh K. Jain9,
  22. W. David Lee7,
  23. Linda G. Griffith13,
  24. Moungi G. Bawendi14,
  25. David G. Kirsch1,8,, and
  26. Brian E. Brigman12,
  1. 1Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA.
  2. 2Medical Science Training Program, Duke University Medical Center, Durham, NC 27710, USA.
  3. 3Department of Pathology, Duke University Medical Center, Durham, NC 27710, USA.
  4. 4School of Medicine, Duke University Medical Center, Durham, NC 27710, USA.
  5. 5Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA.
  6. 6PK/PD Core Laboratory, Duke Cancer Institute, Duke University Medical Center, Durham, NC 27710, USA.
  7. 7Lumicell Inc., Wellesley, MA 02481, USA.
  8. 8Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA.
  9. 9Edwin L. Steele Laboratory, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
  10. 10Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA.
  11. 11Duke Translational Medicine Institute, Regulatory Affairs Group, Duke University Medical Center, NC 27710, USA.
  12. 12Department of Orthopaedic Surgery, Duke University Medical Center, Durham, NC 27710, USA.
  13. 13Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.
  14. 14Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.
  1. Corresponding author. E-mail: david.kirsch{at}duke.edu
    • * Present address: Department of Pathology, NYU Langone Medical Center, New York, NY 10016, USA.

    • Co-senior authors.

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