Data gaps limit the translational potential of preclinical research

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Science Translational Medicine  06 Jan 2016:
Vol. 8, Issue 320, pp. 320ps1
DOI: 10.1126/scitranslmed.aac9888


The absence of mouse pharmacokinetic reference data hinders translation. An analysis of recent literature highlights a systematic lack of discussion regarding rationale for the selection of dosing paradigms in preclinical studies, and in particular for neuroscience studies in which the lack of brain penetration can limit target-organ exposure. We propose solutions to improve study design.

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