Contents
06 January 2016
Vol 8, Issue 320
Vol 8, Issue 320
Contents
Perspective
- Data gaps limit the translational potential of preclinical research
The absence of mouse pharmacokinetic reference data hinders translation of preclinical research.
Research Articles
- Increased internalization of complement inhibitor CD59 may contribute to endothelial inflammation in obstructive sleep apnea
Reduced protection against complement attack mediates endothelial inflammation in obstructive sleep apnea.
- Sources of HIV infection among men having sex with men and implications for prevention
Available antiretrovirals both for treatment and prevention and more comprehensive HIV testing would have prevented the majority of past, annual HIV transmissions among MSM in the Netherlands, but none of the three interventions in isolation.
- Early memory phenotypes drive T cell proliferation in patients with pediatric malignancies
Enriching stem central memory cells rescues poor T cell expansion, expanding patient eligibility for cellular therapy.
- A mouse-human phase 1 co-clinical trial of a protease-activated fluorescent probe for imaging cancer
A first-in-human phase 1 clinical trial of the PEGylated protease-activated fluorescent probe, LUM015, enables tumor imaging at a safe and tolerable dose in humans.
Editors' Choice
- Is Huntington’s disease a neurodevelopmental disorder?
Gene expression analysis of patient-derived Huntington’s disease neural stem cells and corrected isogenic controls suggests that the first steps in disease pathogenesis may occur during fetal development.
- Eating at the right time
Misalignment of feeding and sleeping schedules can disrupt learning and memory, a concern for shift workers.
- Influenza antibody archaeology
Broadly neutralizing antibodies against influenza viruses evolve in a stepwise process that begins with strain-specific antibodies.
About The Cover
ONLINE COVER Statins Complement OSA Treatment. Obstructive sleep apnea (OSA) is a common medical condition associated with temporary cessation of breathing during sleep. It is usually treated by applying continuous positive airway pressure during sleep, as shown in this image. Now, Emin et al. have found that drugs called statins may also have a beneficial effect in OSA by protecting blood vessels from complement-induced damage caused by intermittent oxygen deprivation. [CREDIT: JUANMONINO/ISTOCKPHOTO]
