The transient receptor potential vanilloid 4 channel modulates uterine tone during pregnancy

Lihua Ying; Margaux Becard; Deirdre Lyell; Xiaoyuan Han; Linda Shortliffe; Cristiana Iosef Husted; Cristina M. Alvira; David N. Cornfield

doi:10.1126/scitranslmed.aad0376

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The transient receptor potential vanilloid 4 channel modulates uterine tone during pregnancy

Lihua Ying¹,
Margaux Becard²,
Deirdre Lyell³,
Xiaoyuan Han⁴,
Linda Shortliffe⁴,
Cristiana Iosef Husted⁵,
Cristina M. Alvira¹,⁶,* and
David N. Cornfield¹,⁶,⁷,*,†

¹Center for Excellence in Pulmonary Biology, Stanford University Medical School, Stanford, CA 94305, USA.
²Pôle Mère, Département de Gynécologie Obstétrique, Centre Hospitalier de Calais, Calais 62100, France.
³Departments of Pediatrics and Obstetrics and Gynecology, Stanford University Medical School, Stanford, CA 94305, USA.
⁴Department of Urology, Stanford University Medical School, Stanford, CA 94305, USA.
⁵Department of Biochemistry and Molecular Biology, School of Medicine, University of Nevada, Reno, CA 89557, USA.
⁶Divisions of Pulmonary, Asthma and Sleep Medicine, Stanford University Medical School, Stanford, CA 94305, USA.
⁷Division of Critical Care Medicine, Stanford University Medical School, Stanford, CA 94305, USA.

↵†Corresponding author. E-mail: cornfield{at}stanford.edu

↵* These authors are co-senior authors.

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Science Translational Medicine 23 Dec 2015:
Vol. 7, Issue 319, pp. 319ra204
DOI: 10.1126/scitranslmed.aad0376

Lihua Ying

1Center for Excellence in Pulmonary Biology, Stanford University Medical School, Stanford, CA 94305, USA.

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Margaux Becard

2Pôle Mère, Département de Gynécologie Obstétrique, Centre Hospitalier de Calais, Calais 62100, France.

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Deirdre Lyell

3Departments of Pediatrics and Obstetrics and Gynecology, Stanford University Medical School, Stanford, CA 94305, USA.

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Xiaoyuan Han

4Department of Urology, Stanford University Medical School, Stanford, CA 94305, USA.

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Linda Shortliffe

4Department of Urology, Stanford University Medical School, Stanford, CA 94305, USA.

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Cristiana Iosef Husted

5Department of Biochemistry and Molecular Biology, School of Medicine, University of Nevada, Reno, CA 89557, USA.

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Cristina M. Alvira

1Center for Excellence in Pulmonary Biology, Stanford University Medical School, Stanford, CA 94305, USA.

6Divisions of Pulmonary, Asthma and Sleep Medicine, Stanford University Medical School, Stanford, CA 94305, USA.

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David N. Cornfield

1Center for Excellence in Pulmonary Biology, Stanford University Medical School, Stanford, CA 94305, USA.

6Divisions of Pulmonary, Asthma and Sleep Medicine, Stanford University Medical School, Stanford, CA 94305, USA.

7Division of Critical Care Medicine, Stanford University Medical School, Stanford, CA 94305, USA.

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For correspondence: cornfield@stanford.edu

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The transient receptor potential vanilloid 4 channel modulates uterine tone during pregnancy

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