Contents
Vol 7, Issue 319
Contents
Focus
- Translational cancer research comes of age in Latin America
The U.S.–Latin America Cancer Research Network strives to expand translational research capabilities and forge new collaborations.
- Reapplying the uterine brake in preterm labor
Blocking the transient receptor potential vanilloid 4 (TRPV4) channel may be a viable new therapeutic approach to preterm labor (Ying et al., this issue).
Research Articles
- The transient receptor potential vanilloid 4 channel modulates uterine tone during pregnancy
TRPV4 channel activity determines myometrial tone and may be a target for treating preterm labor.
- Development of a therapeutic monoclonal antibody that targets secreted fatty acid–binding protein aP2 to treat type 2 diabetes
A monoclonal antibody to fatty acid–binding protein aP2 has antidiabetic effects on glucose output and utilization.
- Virologic effects of broadly neutralizing antibody VRC01 administration during chronic HIV-1 infection
A single infusion with broadly neutralizing antibody VRC01 resulted in lowered plasma virus load in HIV-1–infected subjects.
- Pacemaker-induced transient asynchrony suppresses heart failure progression
Transient asynchrony induced by an implanted pacemaker improves pathobiology of heart failure in large animals.
Editors' Choice
- Daddy dearest: Obesity alters the sperm epigenome
Obesity and weight loss trigger epigenetic changes in sperm.
- Efficacy by design
Biomaterial-stabilized delivery of microRNA molecules abrogates tumors in a recalcitrant triple-negative breast cancer mouse model.
- Neutrophils: Harbingers of metastasis?
Infiltrating neutrophils release lipid mediators to enhance lung metastasis.
- A shocking development
Shock wave therapy may eventually be an alternative to surgical removal of infected implanted medical devices.
Errata
About The Cover

ONLINE COVER Helping Babies Stay in the Womb. This image shows a rat fetus similar to those used by Ying and coauthors to discover the role of TRPV4 in preterm labor. The authors studied human and rat tissue samples, as well as pregnant rats, and showed that a calcium channel called TRPV4 gradually builds up during pregnancy, increasing the likelihood of uterine contraction closer to term. They also demonstrated that a chemical inhibitor of TRPV4 can successfully prolong pregnancy in two rat models of preterm labor, suggesting that this could be a viable therapeutic approach. A related Focus by Smith discusses the findings. [CREDIT: SCIENCE PICTURES, LTD/SCIENCE SOURCE]