Contents

Contents

• Focus

  • Translational cancer research comes of age in Latin America

    By Investigators of the U.S.–Latin America Cancer Research Network

    Science Translational Medicine23 Dec 2015 : 319fs50 Full AccessRestricted Access

    The U.S.–Latin America Cancer Research Network strives to expand translational research capabilities and forge new collaborations.

    • Abstract
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    • Supplementary Materials

  • Reapplying the uterine brake in preterm labor

    By Roger Smith

    Science Translational Medicine23 Dec 2015 : 319fs51 Full AccessRestricted Access

    Blocking the transient receptor potential vanilloid 4 (TRPV4) channel may be a viable new therapeutic approach to preterm labor (Ying et al., this issue).

    • Abstract
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• Research Articles

  • The transient receptor potential vanilloid 4 channel modulates uterine tone during pregnancy

    By Lihua Ying, Margaux Becard, Deirdre Lyell, Xiaoyuan Han, Linda Shortliffe, Cristiana Iosef Husted, Cristina M. Alvira, David N. Cornfield

    Science Translational Medicine23 Dec 2015 : 319ra204 Full AccessRestricted Access

    TRPV4 channel activity determines myometrial tone and may be a target for treating preterm labor.

    • Editor's Summary
    • Abstract
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    • Supplementary Materials

  • Development of a therapeutic monoclonal antibody that targets secreted fatty acid–binding protein aP2 to treat type 2 diabetes

    By M. Furkan Burak, Karen E. Inouye, Ariel White, Alexandra Lee, Gurol Tuncman, Ediz S. Calay, Motohiro Sekiya, Amir Tirosh, Kosei Eguchi, Gabriel Birrane, Daniel Lightwood, Louise Howells, Geofrey Odede, Hanna Hailu, Shauna West, Rachel Garlish, Helen Neale, Carl Doyle, Adrian Moore, Gökhan S. Hotamisligil

    Science Translational Medicine23 Dec 2015 : 319ra205 Full AccessRestricted Access

    A monoclonal antibody to fatty acid–binding protein aP2 has antidiabetic effects on glucose output and utilization.

    • Editor's Summary
    • Abstract
    • Full Text
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    • Supplementary Materials

  • Virologic effects of broadly neutralizing antibody VRC01 administration during chronic HIV-1 infection

    By Rebecca M. Lynch, Eli Boritz, Emily E. Coates, Adam DeZure, Patrick Madden, Pamela Costner, Mary E. Enama, Sarah Plummer, Lasonji Holman, Cynthia S. Hendel, Ingelise Gordon, Joseph Casazza, Michelle Conan-Cibotti, Stephen A. Migueles, Randall Tressler, Robert T. Bailer, Adrian McDermott, Sandeep Narpala, Sijy O’Dell, Gideon Wolf, Jeffrey D. Lifson, Brandie A. Freemire, Robert J. Gorelick, Janardan P. Pandey, Sarumathi Mohan, Nicolas Chomont, Remi Fromentin, Tae-Wook Chun, Anthony S. Fauci, Richard M. Schwartz, Richard A. Koup, Daniel C. Douek, Zonghui Hu, Edmund Capparelli, Barney S. Graham, John R. Mascola, Julie E. Ledgerwood, VRC 601 Study Team

    Science Translational Medicine23 Dec 2015 : 319ra206 Full AccessRestricted Access

    A single infusion with broadly neutralizing antibody VRC01 resulted in lowered plasma virus load in HIV-1–infected subjects.

    • Editor's Summary
    • Abstract
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    • Supplementary Materials

  • Pacemaker-induced transient asynchrony suppresses heart failure progression

    By Jonathan A. Kirk, Khalid Chakir, Kyoung Hwan Lee, Edward Karst, Ronald J. Holewinski, Gianluigi Pironti, Richard S. Tunin, Iraklis Pozios, Theodore P. Abraham, Pieter de Tombe, Howard A. Rockman, Jennifer E. Van Eyk, Roger Craig, Taraneh G. Farazi, David A. Kass

    Science Translational Medicine23 Dec 2015 : 319ra207 Full AccessRestricted Access

    Transient asynchrony induced by an implanted pacemaker improves pathobiology of heart failure in large animals.

    • Editor's Summary
    • Abstract
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    • Supplementary Materials

• Editors' Choice

  • Daddy dearest: Obesity alters the sperm epigenome

    By Jessica Alvarez

    Science Translational Medicine23 Dec 2015 : 319ec217 Full AccessRestricted Access

    Obesity and weight loss trigger epigenetic changes in sperm.

    • Full Text

  • Resisting the antitumor immune response

    By Sam Behjati

    Science Translational Medicine23 Dec 2015 : 319ec218 Full AccessRestricted Access

    Loss of PTEN protects tumors from immune attack.

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  • Efficacy by design

    By Kara L. Spiller

    Science Translational Medicine23 Dec 2015 : 319ec219 Full AccessRestricted Access

    Biomaterial-stabilized delivery of microRNA molecules abrogates tumors in a recalcitrant triple-negative breast cancer mouse model.

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  • Neutrophils: Harbingers of metastasis?

    By Ian Y. Wong

    Science Translational Medicine23 Dec 2015 : 319ec220 Full AccessRestricted Access

    Infiltrating neutrophils release lipid mediators to enhance lung metastasis.

    • Full Text

  • A shocking development

    By Nicole M. Bouvier

    Science Translational Medicine23 Dec 2015 : 319ec221 Full AccessRestricted Access

    Shock wave therapy may eventually be an alternative to surgical removal of infected implanted medical devices.

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• Errata

  • Erratum for the Research Article: “Metastatic status of sentinel lymph nodes in melanoma determined noninvasively with multispectral optoacoustic imaging” by I. Stoffels, S. Morscher, I. Helfrich, U. Hillen, J. Lehy, N. C. Burton, T. C. P. Sardella, J. Claussen, T. D. Poeppel, H. S. Bachmann, A. Roesch, K. Griewank, D. Schadendorf, M. Gunzer, J. Klode

    Science Translational Medicine23 Dec 2015 : 319er8 Full AccessRestricted Access

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  • Erratum for the Research Article: “Tracking genetically engineered lymphocytes long-term reveals the dynamics of T cell immunological memory” by G. Oliveira, E. Ruggiero, M. T. L. Stanghellini, N. Cieri, M. D’Agostino, R. Fronza, C. Lulay, F. Dionisio, S. Mastaglio, R. Greco, J. Peccatori, A. Aiuti, A. Ambrosi, L. Biasco, A. Bondanza, A. Lambiase, C. Traversari, L. Vago, C. von Kalle, M. Schmidt, C. Bordignon, F. Ciceri, C. Bonini

    Science Translational Medicine23 Dec 2015 : 319er9 Full AccessRestricted Access

    • Full Text