Research ArticleAutoimmunity

The 20S proteasome core, active within apoptotic exosome-like vesicles, induces autoantibody production and accelerates rejection

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Science Translational Medicine  16 Dec 2015:
Vol. 7, Issue 318, pp. 318ra200
DOI: 10.1126/scitranslmed.aac9816

Article Information

vol. 7 no. 318 318ra200

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication July 13, 2015
  • Accepted for publication November 9, 2015
  • .

Author Information

  1. Mélanie Dieudé1,2,*,
  2. Christina Bell2,3,*,,
  3. Julie Turgeon1,2,
  4. Deborah Beillevaire1,2,
  5. Luc Pomerleau1,2,
  6. Bing Yang1,2,
  7. Katia Hamelin1,2,
  8. Shijie Qi1,2,
  9. Nicolas Pallet1,,
  10. Chanel Béland1,
  11. Wahiba Dhahri1,
  12. Jean-François Cailhier1,2,
  13. Matthieu Rousseau2,4,
  14. Anne-Claire Duchez2,4,
  15. Tania Lévesque2,4,
  16. Arthur Lau2,5,
  17. Christiane Rondeau6,
  18. Diane Gingras6,
  19. Danie Muruve2,5,
  20. Alain Rivard1,
  21. Héloise Cardinal1,2,
  22. Claude Perreault2,3,
  23. Michel Desjardins6,
  24. Éric Boilard2,4,
  25. Pierre Thibault2,3,§, and
  26. Marie-Josée Hébert1,2,§,
  1. 1Research Centre, Centre hospitalier de l’Université de Montréal (CRCHUM), Montréal, Québec G1V 4G2, Canada.
  2. 2Canadian National Transplantation Research Program, Edmonton, Alberta T6G 2E1, Canada.
  3. 3Institute for Research in Immunology and Cancer (IRIC), Montréal, Québec H3T 1JA, Canada.
  4. 4Centre de Recherche du CHU de Québec, Québec, Québec G1V 4G2, Canada.
  5. 5University of Calgary, Calgary, Alberta T2N 1N4, Canada.
  6. 6Université de Montréal, Montréal, Québec H3T 1J4, Canada.
  1. Corresponding author. E-mail: marie-josee.hebert.chum{at}ssss.gouv.qc.ca (M.-J.H.); pierre.thibault{at}umontreal.ca (P.T.)
    • * These authors contributed equally to this work.

    • Present address: Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.

    • Present address: INSERM U1147, 75006 Paris, France.

    • § These authors contributed equally to this work.

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