Contents
16 December 2015
Vol 7, Issue 318
Vol 7, Issue 318
Contents
Focus
- Academic clinical research: Death by a thousand clicks
Selected strategies can reduce the administrative burden on researchers and improve efficiency while still achieving clinical and regulatory goals.
Research Articles
- The 20S proteasome core, active within apoptotic exosome-like vesicles, induces autoantibody production and accelerates rejection
Exosome-like vesicles containing an active 20S proteasome core contribute to autoimmunity and vascular allograft inflammation.
- Implantable synthetic cytokine converter cells with AND-gate logic treat experimental psoriasis
Implantable designer cells sense proinflammatory cytokines and coordinate production and delivery of anti-inflammatory molecules to attenuate psoriasis in mice.
- Therapeutic targeting of casein kinase 1δ in breast cancer
Casein kinase 1δ promotes breast tumorigenesis by activation of β-catenin and can be targeted in some breast cancers.
- Improving the spatial resolution of epiretinal implants by increasing stimulus pulse duration
Retinal implants that deliver longer pulses of electrical current may markedly improve image sharpness for blind individuals.
Editors' Choice
- Reprograming Tregs to become tumor killers
CD137 agonist induces Tregs to become cytotoxic.
- AD and CAA: Independent risk factors for dementia
Cerebral amyloid angiopathy, a neurovascular disease of the elderly, is highly prevalent in patients with Alzheimer's disease and is associated independently with dementia.
- Muscle movement and loss
Immobilization causes loss of muscle by decreasing its protein synthesis and response to feeding.
- Engineering tumors by rolling sheets
Three-dimensional engineered tumors can recapitulate the hypoxic gradient of in vivo tumors.
Letters
- Comment on “Dengue virus NS1 protein activates cells via Toll-like receptor 4 and disrupts endothelial cell monolayer integrity” and “Dengue virus NS1 triggers endothelial permeability and vascular leak that is prevented by NS1 vaccination”
New insights into toxicity of dengue virus protein NS1 provide context to previous work and prompt further questions.
- Response to comment on “Dengue virus NS1 protein activates cells via Toll-like receptor 4 and disrupts endothelial cell monolayer integrity” and “Dengue virus NS1 triggers endothelial permeability and vascular leak that is prevented by NS1 vaccination”
Multiple risk factors may cause progression to severe dengue.
About The Cover
ONLINE COVER It's Logical. There's no cure for psoriasis, an inflammatory skin disease that is itchy, red, and scaly. In this issue, Fussenegger and colleagues describe a potential new treatment for psoriasis using synthetic biology tools. The authors engineered human cells to contain AND logic gates, where two inputs—cytokines overexpressed in psoriasis, IL-22 and TNF—triggered the cell's machinery to produce two therapeutic cytokine outputs, IL-4 and IL-10. When implanted in mice, the so-called cytokine converter cells responded to acute and established disease, reducing the severity of psoriatic lesions for days. [CREDIT: C. BICKEL/SCIENCE TRANSLATIONAL MEDICINE ]