Research ArticleImmunotherapy

Tracking genetically engineered lymphocytes long-term reveals the dynamics of T cell immunological memory

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Science Translational Medicine  09 Dec 2015:
Vol. 7, Issue 317, pp. 317ra198
DOI: 10.1126/scitranslmed.aac8265

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Committing T cells to memory

Adoptive cell transfer is an increasingly successful therapy for a variety of diseases; however, little is known about what regulates the survival of these cells in humans. Now, Oliveira et al. leverage patients who have received genetically modified hematopoietic stem cells to track T cells over time. They found labeled effector memory, central memory, and stem memory T cells 2 to 14 years after infusion in all patients. Antigen recognition was critical in driving persistence and expansion. The clones that survived long-term appeared to initiate preferentially from central and stem cell memory T cell populations. These data suggest that the original phenotype of infused cells may influence long-term persistence of adoptively transferred cells.

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