Contents
09 December 2015
Vol 7, Issue 317
Vol 7, Issue 317
Contents
Perspective
- Ebola vaccine R&D: Filling the knowledge gaps
An Ebola project harnesses state-of-the-art technologies that illuminate mechanisms of vaccine immunogenicity and reactogenicity.
Research Articles
- Recruitment of classical monocytes can be inhibited by disturbing heteromers of neutrophil HNP1 and platelet CCL5
Disrupting the HNP1 and CCL5 heteromer between neutrophils and platelets blocks monocyte recruitment to inflammatory sites.
- RANKL blockade prevents and treats aggressive osteosarcomas
Denosumab, an antibody targeting RANKL, is effective against osteosarcoma in mouse models.
- Tracking genetically engineered lymphocytes long-term reveals the dynamics of T cell immunological memory
Antigen exposure and differentiation phenotype influence long-term persistence of memory T cells after hematopoietic stem cell transplant.
- Metastatic status of sentinel lymph nodes in melanoma determined noninvasively with multispectral optoacoustic imaging
Optoacoustic imaging strategies can be used to identify metastasis in excised lymph nodes and to determine SLN status in patients noninvasively.
Editors' Choice
- Pecking order
Pigeons distinguish clinically relevant features on breast screening pathology slides but not x-ray images.
- Press pause to fast forward
A novel RNA-based device controlling key proteins can effectively and reversibly arrest human cell cycles.
- CREBBP-mutated cancers HAT-tricked
CREBBP-deficient cancer cells are profoundly addicted to EP300, and MYC plays a key role in this interaction.
Letters
- Comment on “One health, one literature: Weaving together veterinary and medical research”
The research community can have confidence in data from well-executed phenotyping projects.
- Response to comment on “One health, one literature: Weaving together veterinary and medical research”
Comparative knowledge is essential for effective preclinical translational research.
About The Cover
ONLINE COVER Sentinels Signal Metastasis. Lymphatic vessels (in green) wind throughout the body, passing through lymph nodes. Sentinel lymph nodes are the first nodes branching off of a tumor and therefore act as a drain for metastatic cells traveling elsewhere. To determine tumor metastasis, patients undergo surgery and biopsy of the sentinel nodes. For patients with melanoma, Stoffels et al. offer an imaging alternative to this invasive procedure: multispectral optoacoustic tomography (MSOT). MSOT can detect the presence of melanin in the sentinel lymph nodes, signaling the presence of metastasized melanoma, as melanin is a pigment not naturally found in the lymphatic system. In patients, MSOT was used to "rule out" metastasis, sparing them invasive biopsies and improving cancer management. [CREDIT: STOCKTREK IMAGES, INC./ALAMY STOCK PHOTO]