Research ArticleKidney Disease
Tissue transcriptome-driven identification of epidermal growth factor as a chronic kidney disease biomarker
- Wenjun Ju1,2,*,†,
- Viji Nair1,†,
- Shahaan Smith1,‡,
- Li Zhu3,
- Kerby Shedden2,4,
- Peter X. K. Song5,
- Laura H. Mariani1,6,
- Felix H. Eichinger1,
- Celine C. Berthier1,
- Ann Randolph1,
- Jennifer Yi-Chun Lai1,
- Yan Zhou5,§,
- Jennifer J. Hawkins1,
- Markus Bitzer1,
- Matthew G. Sampson7,
- Martina Thier8,
- Corinne Solier8,
- Gonzalo C. Duran-Pacheco8,
- Guillemette Duchateau-Nguyen8,
- Laurent Essioux8,
- Brigitte Schott8,
- Ivan Formentini8,
- Maria C. Magnone8,¶,
- Maria Bobadilla8,
- Clemens D. Cohen9,∥,
- Serena M. Bagnasco10,
- Laura Barisoni11,
- Jicheng Lv3,
- Hong Zhang3,
- Hai-Yan Wang3,**,
- Frank C. Brosius1,12,
- Crystal A. Gadegbeku13,
- Matthias Kretzler1,2,*,
- for the ERCB, C-PROBE, NEPTUNE, and PKU-IgAN Consortium
- 1Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA.
- 2Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109, USA.
- 3Renal Division, Department of Internal Medicine, Peking University First Hospital, Peking University Institute of Nephrology, Beijing 100034, China.
- 4Department of Statistics, University of Michigan, Ann Arbor, MI 48109, USA.
- 5Department of Biostatistics, University of Michigan, Ann Arbor, MI 48109, USA.
- 6Arbor Research Collaborative for Health, Ann Arbor, MI 48104, USA.
- 7Department of Pediatrics, University of Michigan, Ann Arbor, MI 48109, USA.
- 8Roche Pharmaceutical Research and Early Development–Roche Innovation Center, 4070 Basel, Switzerland.
- 9Division of Nephrology, Institute of Physiology, University of Zurich, CH-8006 Zürich, Switzerland.
- 10Department of Pathology, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA.
- 11Department of Pathology, Miller School of Medicine, University of Miami, Miami, FL 33136, USA.
- 12Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48109, USA.
- 13Temple Clinical Research Institute, Temple University School of Medicine, Philadelphia, PA 19140, USA.
- ↵*Corresponding author. E-mail: wenjunj{at}med.umich.edu (W.J.); kretzler{at}umich.edu (M.K.)
↵† These authors contributed equally to this work.
↵‡ Present address: Department of Medical Oncology, University of Washington, Seattle, WA 98109, USA.
↵§ Present address: Merck Research Laboratories, North Wales, PA 19454, USA.
↵¶ Present address: Cardiovascular and Metabolic Diseases Innovative Medicines, AstraZeneca R&D, Mölndal SE-431 83, Sweden.
↵∥ Present address: Department for Kidney Disease and Hypertension and Clinical Immunology, Harlaching Hospital, Munich 81545, Germany.
↵** Deceased.
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Science Translational Medicine 02 Dec 2015:
Vol. 7, Issue 316, pp. 316ra193
DOI: 10.1126/scitranslmed.aac7071
Vol. 7, Issue 316, pp. 316ra193
DOI: 10.1126/scitranslmed.aac7071
Wenjun Ju
1Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA.
2Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109, USA.
Viji Nair
1Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA.
Shahaan Smith
1Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA.
Li Zhu
3Renal Division, Department of Internal Medicine, Peking University First Hospital, Peking University Institute of Nephrology, Beijing 100034, China.
Kerby Shedden
2Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109, USA.
4Department of Statistics, University of Michigan, Ann Arbor, MI 48109, USA.
Peter X. K. Song
5Department of Biostatistics, University of Michigan, Ann Arbor, MI 48109, USA.
Laura H. Mariani
1Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA.
6Arbor Research Collaborative for Health, Ann Arbor, MI 48104, USA.
Felix H. Eichinger
1Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA.
Celine C. Berthier
1Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA.
Ann Randolph
1Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA.
Jennifer Yi-Chun Lai
1Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA.
Yan Zhou
5Department of Biostatistics, University of Michigan, Ann Arbor, MI 48109, USA.
Jennifer J. Hawkins
1Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA.
Markus Bitzer
1Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA.
Matthew G. Sampson
7Department of Pediatrics, University of Michigan, Ann Arbor, MI 48109, USA.
Martina Thier
8Roche Pharmaceutical Research and Early Development–Roche Innovation Center, 4070 Basel, Switzerland.
Corinne Solier
8Roche Pharmaceutical Research and Early Development–Roche Innovation Center, 4070 Basel, Switzerland.
Gonzalo C. Duran-Pacheco
8Roche Pharmaceutical Research and Early Development–Roche Innovation Center, 4070 Basel, Switzerland.
Guillemette Duchateau-Nguyen
8Roche Pharmaceutical Research and Early Development–Roche Innovation Center, 4070 Basel, Switzerland.
Laurent Essioux
8Roche Pharmaceutical Research and Early Development–Roche Innovation Center, 4070 Basel, Switzerland.
Brigitte Schott
8Roche Pharmaceutical Research and Early Development–Roche Innovation Center, 4070 Basel, Switzerland.
Ivan Formentini
8Roche Pharmaceutical Research and Early Development–Roche Innovation Center, 4070 Basel, Switzerland.
Maria C. Magnone
8Roche Pharmaceutical Research and Early Development–Roche Innovation Center, 4070 Basel, Switzerland.
Maria Bobadilla
8Roche Pharmaceutical Research and Early Development–Roche Innovation Center, 4070 Basel, Switzerland.
Clemens D. Cohen
9Division of Nephrology, Institute of Physiology, University of Zurich, CH-8006 Zürich, Switzerland.
Serena M. Bagnasco
10Department of Pathology, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA.
Laura Barisoni
11Department of Pathology, Miller School of Medicine, University of Miami, Miami, FL 33136, USA.
Jicheng Lv
3Renal Division, Department of Internal Medicine, Peking University First Hospital, Peking University Institute of Nephrology, Beijing 100034, China.
Hong Zhang
3Renal Division, Department of Internal Medicine, Peking University First Hospital, Peking University Institute of Nephrology, Beijing 100034, China.
Hai-Yan Wang
3Renal Division, Department of Internal Medicine, Peking University First Hospital, Peking University Institute of Nephrology, Beijing 100034, China.
Frank C. Brosius
1Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA.
12Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48109, USA.
Crystal A. Gadegbeku
13Temple Clinical Research Institute, Temple University School of Medicine, Philadelphia, PA 19140, USA.
Matthias Kretzler
1Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA.
2Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109, USA.
