Research ArticleKidney Disease

Tissue transcriptome-driven identification of epidermal growth factor as a chronic kidney disease biomarker

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Science Translational Medicine  02 Dec 2015:
Vol. 7, Issue 316, pp. 316ra193
DOI: 10.1126/scitranslmed.aac7071

Urine marker to the rescue

Chronic kidney disease is a common medical problem worldwide, but it is difficult to predict which patients are more likely to progress to end-stage disease and need aggressive management. Ju et al. have now drawn on four independent cohorts totaling hundreds of patients from around the world to identify the expression of epidermal growth factor (EGF) in the kidneys as a marker of kidney disease progression. Moreover, the authors demonstrated that the amount of EGF in the urine is just as useful, providing a biomarker that can be easily tracked over time without requiring invasive biopsies.

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