Research ArticleGraft-Versus-Host Disease

Transcriptome analysis of GVHD reveals aurora kinase A as a targetable pathway for disease prevention

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Science Translational Medicine  25 Nov 2015:
Vol. 7, Issue 315, pp. 315ra191
DOI: 10.1126/scitranslmed.aad3231

Dawn of new graft-versus-host disease therapies

Hematopoietic stem cell transplant (HCT) is a common therapy for patients with damaged bone marrow or immunodeficiencies. However, HCT has its own risks: In cases where the donor is not a perfect match to the recipient, immune cells derived from the graft can attack their new home. Furlan et al. examined the gene expression profile of nonhuman primate T cells during acute graft-versus-host disease (GVHD). The transcriptomics signatures specific for alloreactive T cells identified pathways altered during acute GVHD that could serve as therapeutic targets. The authors then examined one target in particular, aurora kinase A, and demonstrated that pharmacologic inhibition could improve survival in a mouse model of GVHD.

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