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Research ArticleRheumatoid Arthritis
Neutrophil-derived microvesicles enter cartilage and protect the joint in inflammatory arthritis
- Sarah E. Headland1,
- Hefin R. Jones1,
- Lucy V. Norling1,
- Andrew Kim2,
- Patricia R. Souza1,
- Elisa Corsiero1,
- Cristiane D. Gil3,
- Alessandra Nerviani1,
- Francesco Dell’Accio1,4,
- Costantino Pitzalis1,4,
- Sonia M. Oliani3,
- Lily Y. Jan2 and
- Mauro Perretti1,*
- 1William Harvey Research Institute, Barts and The London School of Medicine, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK.
- 2Department of Physiology, Howard Hughes Medical Institute, University of California, San Francisco, San Francisco, CA 94143, USA.
- 3Department of Biology, Instituto de Biociências, Letras e Ciências Exatas, São Paulo State University (UNESP), São José do Rio Preto 15054-000, Brazil.
- 4Department of Rheumatology, Barts Health Trust, Bancroft Road, London E1 4DG, UK.
- ↵*Corresponding author. E-mail: m.perretti{at}qmul.ac.uk
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Science Translational Medicine 25 Nov 2015:
Vol. 7, Issue 315, pp. 315ra190
DOI: 10.1126/scitranslmed.aac5608
Vol. 7, Issue 315, pp. 315ra190
DOI: 10.1126/scitranslmed.aac5608
Sarah E. Headland
1William Harvey Research Institute, Barts and The London School of Medicine, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK.
Hefin R. Jones
1William Harvey Research Institute, Barts and The London School of Medicine, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK.
Lucy V. Norling
1William Harvey Research Institute, Barts and The London School of Medicine, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK.
Andrew Kim
2Department of Physiology, Howard Hughes Medical Institute, University of California, San Francisco, San Francisco, CA 94143, USA.
Patricia R. Souza
1William Harvey Research Institute, Barts and The London School of Medicine, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK.
Elisa Corsiero
1William Harvey Research Institute, Barts and The London School of Medicine, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK.
Cristiane D. Gil
3Department of Biology, Instituto de Biociências, Letras e Ciências Exatas, São Paulo State University (UNESP), São José do Rio Preto 15054-000, Brazil.
Alessandra Nerviani
1William Harvey Research Institute, Barts and The London School of Medicine, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK.
Francesco Dell’Accio
1William Harvey Research Institute, Barts and The London School of Medicine, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK.
4Department of Rheumatology, Barts Health Trust, Bancroft Road, London E1 4DG, UK.
Costantino Pitzalis
1William Harvey Research Institute, Barts and The London School of Medicine, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK.
4Department of Rheumatology, Barts Health Trust, Bancroft Road, London E1 4DG, UK.
Sonia M. Oliani
3Department of Biology, Instituto de Biociências, Letras e Ciências Exatas, São Paulo State University (UNESP), São José do Rio Preto 15054-000, Brazil.
Lily Y. Jan
2Department of Physiology, Howard Hughes Medical Institute, University of California, San Francisco, San Francisco, CA 94143, USA.
Mauro Perretti
1William Harvey Research Institute, Barts and The London School of Medicine, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK.
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