Neutrophil-derived microvesicles enter cartilage and protect the joint in inflammatory arthritis

Sarah E. Headland; Hefin R. Jones; Lucy V. Norling; Andrew Kim; Patricia R. Souza; Elisa Corsiero; Cristiane D. Gil; Alessandra Nerviani; Francesco Dell’Accio; Costantino Pitzalis; Sonia M. Oliani; Lily Y. Jan; Mauro Perretti

doi:10.1126/scitranslmed.aac5608

Research ArticleRheumatoid Arthritis

Neutrophil-derived microvesicles enter cartilage and protect the joint in inflammatory arthritis

Sarah E. Headland¹,
Hefin R. Jones¹,
Lucy V. Norling¹,
Andrew Kim²,
Patricia R. Souza¹,
Elisa Corsiero¹,
Cristiane D. Gil³,
Alessandra Nerviani¹,
Francesco Dell’Accio¹,⁴,
Costantino Pitzalis¹,⁴,
Sonia M. Oliani³,
Lily Y. Jan² and
Mauro Perretti¹,*

¹William Harvey Research Institute, Barts and The London School of Medicine, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK.
²Department of Physiology, Howard Hughes Medical Institute, University of California, San Francisco, San Francisco, CA 94143, USA.
³Department of Biology, Instituto de Biociências, Letras e Ciências Exatas, São Paulo State University (UNESP), São José do Rio Preto 15054-000, Brazil.
⁴Department of Rheumatology, Barts Health Trust, Bancroft Road, London E1 4DG, UK.

↵*Corresponding author. E-mail: m.perretti{at}qmul.ac.uk

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Science Translational Medicine 25 Nov 2015:
Vol. 7, Issue 315, pp. 315ra190
DOI: 10.1126/scitranslmed.aac5608

Sarah E. Headland

1William Harvey Research Institute, Barts and The London School of Medicine, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK.

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Hefin R. Jones

1William Harvey Research Institute, Barts and The London School of Medicine, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK.

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Lucy V. Norling

1William Harvey Research Institute, Barts and The London School of Medicine, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK.

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Andrew Kim

2Department of Physiology, Howard Hughes Medical Institute, University of California, San Francisco, San Francisco, CA 94143, USA.

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Patricia R. Souza

1William Harvey Research Institute, Barts and The London School of Medicine, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK.

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Elisa Corsiero

1William Harvey Research Institute, Barts and The London School of Medicine, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK.

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Cristiane D. Gil

3Department of Biology, Instituto de Biociências, Letras e Ciências Exatas, São Paulo State University (UNESP), São José do Rio Preto 15054-000, Brazil.

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Alessandra Nerviani

1William Harvey Research Institute, Barts and The London School of Medicine, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK.

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Francesco Dell’Accio

1William Harvey Research Institute, Barts and The London School of Medicine, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK.

4Department of Rheumatology, Barts Health Trust, Bancroft Road, London E1 4DG, UK.

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Costantino Pitzalis

1William Harvey Research Institute, Barts and The London School of Medicine, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK.

4Department of Rheumatology, Barts Health Trust, Bancroft Road, London E1 4DG, UK.

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Sonia M. Oliani

3Department of Biology, Instituto de Biociências, Letras e Ciências Exatas, São Paulo State University (UNESP), São José do Rio Preto 15054-000, Brazil.

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Lily Y. Jan

2Department of Physiology, Howard Hughes Medical Institute, University of California, San Francisco, San Francisco, CA 94143, USA.

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Mauro Perretti

1William Harvey Research Institute, Barts and The London School of Medicine, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK.

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For correspondence: m.perretti@qmul.ac.uk

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Neutrophil-derived microvesicles enter cartilage and protect the joint in inflammatory arthritis

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