Research ArticleRheumatoid Arthritis

Neutrophil-derived microvesicles enter cartilage and protect the joint in inflammatory arthritis

See allHide authors and affiliations

Science Translational Medicine  25 Nov 2015:
Vol. 7, Issue 315, pp. 315ra190
DOI: 10.1126/scitranslmed.aac5608

You are currently viewing the editor's summary.

View Full Text

Log in to view the full text

Log in through your institution

Log in through your institution

Microparticles provide protection

Neutrophils play an active role in protecting cartilage from damage by dispatching microvesicles (MVs) to do their bidding in this tissue they otherwise can’t access. Headland and colleagues found MVs present in the synovial fluid of patients with rheumatoid arthritis—an autoimmune disease that degrades cartilage in the joints. Cartilage is normally thought of as impenetrable to cells, so neutrophils send MVs, which easily enter the tissue and prevent damage induced by disease through a complex mechanism that involves the proresolving protein annexin A1 and its receptor. In two different mouse models of rheumatoid arthritis, MVs delivered locally entered the cartilage, prevented the loss of proteoglycans, and maintained cartilage integrity. This study suggests that immune cells can provide protection against tissue degradation in inflammatory arthritis and that the MVs may be manipulated to deliver therapeutics to diseased joints.

View Full Text