25 November 2015
Vol 7, Issue 315
  • Contents

    • Focus

      • Is all cancer therapy immunotherapy?

        Researchers must renew efforts to decipher how standard chemotherapies enhance the effects of targeted immunotherapeutic agents (Müller et al., this issue).

    • Perspective

    • Research Articles

    • Editors' Choice

      • Wanna be statin something?

        Statins may prove useful in reducing inflammation in COPD.

      • Big dipper, little dipper

        Individuals with an impaired cerebrovascular system are more likely to show increased brain amyloid deposition, potentially a therapeutic opportunity for treating Alzheimer’s disease.

      • All systems go for HIV vaccine development

        Systematically mapping diverse antibody effector functions induced by candidate HIV vaccines moves toward pinpointing a protective strategy.

      • A Notch in our understanding of vascular disease

        Atherosclerosis triggers a decrease in endothelial cell Notch expression, affecting vascular homeostasis and disease susceptibility.

      • Above the landscape

        The metabolome regulates the epigenetic landscape in human pluripotent stem cells.

About The Cover

Cover image expansion

ONLINE COVER Shedding Light on Graft-Versus-Host Disease. The Aurora borealis (shown) lights up the night sky. In this issue of Science Translational Medicine, Furlan et al. identify a different type of aurora–aurora kinase A—as a potential therapeutic target for graft-versus-host disease after hematopoietic stem cell transplant. [CREDIT: N. PANDEV/ISTOCKPHOTO]