Bioengineered vocal fold mucosa for voice restoration

Changying Ling; Qiyao Li; Matthew E. Brown; Yo Kishimoto; Yutaka Toya; Erin E. Devine; Kyeong-Ok Choi; Kohei Nishimoto; Ian G. Norman; Tenzin Tsegyal; Jack J. Jiang; William J. Burlingham; Sundaram Gunasekaran; Lloyd M. Smith; Brian L. Frey; Nathan V. Welham

doi:10.1126/scitranslmed.aab4014

Research ArticleTissue Engineering

Bioengineered vocal fold mucosa for voice restoration

Changying Ling¹,
Qiyao Li²,
Matthew E. Brown³,
Yo Kishimoto¹,*,
Yutaka Toya¹,†,
Erin E. Devine¹,
Kyeong-Ok Choi⁴,
Kohei Nishimoto¹,
Ian G. Norman³,
Tenzin Tsegyal¹,
Jack J. Jiang¹,
William J. Burlingham³,
Sundaram Gunasekaran⁴,
Lloyd M. Smith²,
Brian L. Frey² and
Nathan V. Welham¹,‡

¹Division of Otolaryngology–Head and Neck Surgery, Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792, USA.
²Department of Chemistry, University of Wisconsin-Madison, Madison, WI 53706, USA.
³Division of Transplantation, Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792, USA.
⁴Department of Biological Systems Engineering, University of Wisconsin-Madison, Madison, WI 53706, USA.

↵‡Corresponding author. E-mail: welham{at}surgery.wisc.edu

↵* Present address: Department of Otolaryngology–Head and Neck Surgery, Kyoto University, Kyoto 606-8507, Japan.
↵† Present address: Department of Otolaryngology–Head and Neck Surgery, Kumamoto University, Kumamoto 860-8556, Japan.

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Science Translational Medicine 18 Nov 2015:
Vol. 7, Issue 314, pp. 314ra187
DOI: 10.1126/scitranslmed.aab4014

Changying Ling

1Division of Otolaryngology–Head and Neck Surgery, Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792, USA.

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Qiyao Li

2Department of Chemistry, University of Wisconsin-Madison, Madison, WI 53706, USA.

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Matthew E. Brown

3Division of Transplantation, Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792, USA.

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Yo Kishimoto

1Division of Otolaryngology–Head and Neck Surgery, Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792, USA.

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Yutaka Toya

1Division of Otolaryngology–Head and Neck Surgery, Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792, USA.

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Erin E. Devine

1Division of Otolaryngology–Head and Neck Surgery, Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792, USA.

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Kyeong-Ok Choi

4Department of Biological Systems Engineering, University of Wisconsin-Madison, Madison, WI 53706, USA.

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Kohei Nishimoto

1Division of Otolaryngology–Head and Neck Surgery, Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792, USA.

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Ian G. Norman

3Division of Transplantation, Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792, USA.

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Tenzin Tsegyal

1Division of Otolaryngology–Head and Neck Surgery, Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792, USA.

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Jack J. Jiang

1Division of Otolaryngology–Head and Neck Surgery, Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792, USA.

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William J. Burlingham

3Division of Transplantation, Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792, USA.

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Sundaram Gunasekaran

4Department of Biological Systems Engineering, University of Wisconsin-Madison, Madison, WI 53706, USA.

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Lloyd M. Smith

2Department of Chemistry, University of Wisconsin-Madison, Madison, WI 53706, USA.

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Brian L. Frey

2Department of Chemistry, University of Wisconsin-Madison, Madison, WI 53706, USA.

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Nathan V. Welham

1Division of Otolaryngology–Head and Neck Surgery, Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792, USA.

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For correspondence: welham@surgery.wisc.edu

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Primary human vocal fold mucosal cells recapitulate native physiologic function, offering voice restoration to patients with advanced laryngeal disease.

Bioengineered vocal fold mucosa for voice restoration

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