Research ArticleCancer

AZD9150, a next-generation antisense oligonucleotide inhibitor of STAT3 with early evidence of clinical activity in lymphoma and lung cancer

See allHide authors and affiliations

Science Translational Medicine  18 Nov 2015:
Vol. 7, Issue 314, pp. 314ra185
DOI: 10.1126/scitranslmed.aac5272

Article Information

vol. 7 no. 314 314ra185

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication May 7, 2015
  • Accepted for publication October 6, 2015
  • .

Author Information

  1. David Hong1,*,
  2. Razelle Kurzrock2,*,,
  3. Youngsoo Kim3,*,
  4. Richard Woessner4,
  5. Anas Younes5,
  6. John Nemunaitis6,
  7. Nathan Fowler1,
  8. Tianyuan Zhou3,
  9. Joanna Schmidt3,
  10. Minji Jo3,
  11. Samantha J. Lee3,
  12. Mason Yamashita3,
  13. Steven G. Hughes3,
  14. Luis Fayad1,
  15. Sarina Piha-Paul1,
  16. Murali V. P. Nadella7,
  17. Morvarid Mohseni4,
  18. Deborah Lawson4,
  19. Corinne Reimer4,
  20. David C. Blakey8,
  21. Xiaokun Xiao3,
  22. Jeff Hsu3,
  23. Alexey Revenko3,
  24. Brett P. Monia3 and
  25. A. Robert MacLeod3,
  1. 1The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA.
  2. 2UC San Diego Moores Cancer Center, 3855 Health Sciences Drive, La Jolla, CA 92093, USA.
  3. 3Department of Antisense Drug Discovery, Isis Pharmaceuticals Inc., 2855 Gazelle Court, Carlsbad, CA 92008, USA.
  4. 4Cancer Bioscience Drug Discovery, AstraZeneca Pharmaceuticals, 35 Gatehouse Drive, Waltham, MA 02451, USA.
  5. 5Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA.
  6. 6Mary Crowley Cancer Research Center, 7777 Forest Lane, Dallas, TX 75230, USA.
  7. 7Drug Safety and Metabolism, AstraZeneca Pharmaceuticals, Waltham, MA 02451, USA.
  8. 8Oncology iMED, AstraZeneca Pharmaceuticals, Alderley Park, Macclesfield SK10 4TF, UK.
  1. Corresponding author. E-mail: rkurzrock{at}mail.ucsd.edu (R.K.); rmacleod{at}isisph.com (A.R.M.)
    • * These authors contributed equally to this work.

    Altmetric

    Article usage

    Article usage: November 2015 to August 2019

    AbstractFullPdf
    Nov 20151645397847
    Dec 2015427115246
    Jan 201638957140
    Feb 20163616591
    Mar 201636258104
    Apr 20162393887
    May 20162815275
    Jun 20162825185
    Jul 20162414157
    Aug 20163104889
    Sep 20162244183
    Oct 20162674750
    Nov 20162794663
    Dec 20162064548
    Jan 20172905371
    Feb 20171822449
    Mar 20171494037
    Apr 20171312640
    May 20171502330
    Jun 20172624448
    Jul 20172122645
    Aug 20172304251
    Sep 20171913341
    Oct 20172002732
    Nov 20171651832
    Dec 20171371523
    Jan 20181613326
    Feb 20181591843
    Mar 20181802835
    Apr 20181682640
    May 20181842434
    Jun 20181923646
    Jul 20181582025
    Aug 2018983145
    Sep 2018834026
    Oct 20181553955
    Nov 20181303644
    Dec 20181103219
    Jan 20191142834
    Feb 2019812730
    Mar 2019953647
    Apr 2019583250
    May 2019571922
    Jun 2019543337
    Jul 2019533824
    Aug 2019672019