Contents
18 November 2015
Vol 7, Issue 314
Vol 7, Issue 314
Contents
Editorial
- Africa’s leadership in biomedical research: Shifting the center of gravity
The Wellcome Trust is shifting management of an initiative to train African research leaders to the continent itself.
Focus
- Nanomedicine gets personal
Companion nanoparticle imaging merges with drug delivery technologies toward personalized nanomedicine (Miller et al., this issue).
Research Articles
- Predicting therapeutic nanomedicine efficacy using a companion magnetic resonance imaging nanoparticle
Magnetic nanoparticles predict the efficacy of drug-loaded polymeric nanoparticles in vivo, helping select for tumors more responsive to nanomedicine.
- The E3 ubiquitin ligase Idol controls brain LDL receptor expression, ApoE clearance, and Aβ amyloidosis
Inhibiting the E3 ubiquitin ligase Idol in a mouse model of Alzheimer’s-like pathology ameliorates disease severity by promoting clearance of Aβ peptides by microglia.
- AZD9150, a next-generation antisense oligonucleotide inhibitor of STAT3 with early evidence of clinical activity in lymphoma and lung cancer
Systemically administered antisense oligonucleotide AZD9150 inhibits STAT3 and shows anticancer activity in preclinical models and patients.
- Targeting LGR5+ cells with an antibody-drug conjugate for the treatment of colon cancer
An antibody-drug conjugate targeting LGR5 effectively treats intestinal cancer in preclinical models.
- Bioengineered vocal fold mucosa for voice restoration
Primary human vocal fold mucosal cells recapitulate native physiologic function, offering voice restoration to patients with advanced laryngeal disease.
Editors' Choice
- Inflammasome activation to protect against colorectal cancer metastasis?
Inflammasome activation promotes NK cell responses to prevent colorectal cancer metastasis.
- A new recipe for serotonergic neurons
Serotonergic neurons derived directly from human skin fibroblasts may be useful for in vitro modeling of neuropsychiatric disorders.
- Protease inhibitor passes oral exam
A bacterial protease inhibitor enables oral vaccination by protecting antigens from gastrointestinal proteases.
- Polypharmacy repercussions
The effect of statins on flu vaccine responses reminds us that such hidden interactions can skew the interpretation of clinical data.
Letters
- Comment on “Antibodies to influenza nucleoprotein cross-react with human hypocretin receptor 2”
Hypocretin receptors are not autoreceptors to hypocretin neurons.
- Response to comment on “Antibodies to influenza nucleoprotein cross-react with human hypocretin receptor 2”
Similarity between influenza nucleoprotein and hypocretin receptor 2 may trigger vaccine-associated narcolepsy.
Podcast
- Science Translational Medicine Podcast: 18 November 2015
Nathan Welham describes an engineered vocal fold mucosa that shows promise for restoring voice to patients with some types of dysphonia.
About The Cover
ONLINE COVER Wellcome to Africa. Movement through the departures gate at Heathrow airport in London, shown in this week's cover photo, conjures the anticipation of international travel to fresh locales. In an Editorial, Kay describes a trip abroad planned by the Wellcome Trust, a U.K.-based foundation that supports biomedical research. The foundation will relocate–from London to Nairobi–its initiatives for training the next generation of African scientific leaders, so that research and funding decisions can be made locally by domestic innovators. [CREDIT: B. LEWIS/ALAMY STOCK PHOTO]