Analysis of ESR1 mutation in circulating tumor DNA demonstrates evolution during therapy for metastatic breast cancer

Gaia Schiavon; Sarah Hrebien; Isaac Garcia-Murillas; Rosalind J. Cutts; Alex Pearson; Noelia Tarazona; Kerry Fenwick; Iwanka Kozarewa; Elena Lopez-Knowles; Ricardo Ribas; Ashutosh Nerurkar; Peter Osin; Sarat Chandarlapaty; Lesley-Ann Martin; Mitch Dowsett; Ian E. Smith; Nicholas C. Turner

doi:10.1126/scitranslmed.aac7551

Research ArticleCancer

Analysis of ESR1 mutation in circulating tumor DNA demonstrates evolution during therapy for metastatic breast cancer

Gaia Schiavon¹,²,*,
Sarah Hrebien¹,
Isaac Garcia-Murillas¹,
Rosalind J. Cutts¹,
Alex Pearson¹,
Noelia Tarazona¹,
Kerry Fenwick¹,
Iwanka Kozarewa¹,
Elena Lopez-Knowles¹,
Ricardo Ribas¹,
Ashutosh Nerurkar²,
Peter Osin²,
Sarat Chandarlapaty³,
Lesley-Ann Martin¹,
Mitch Dowsett¹,²,
Ian E. Smith¹,² and
Nicholas C. Turner¹,²,†

¹The Breast Cancer Now Research Centre, The Institute of Cancer Research, London SW3 6JB, UK.
²Breast Unit, Royal Marsden Hospital, Fulham Road, London SW3 6JJ, UK.
³Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

↵†Corresponding author. E-mail: nicholas.turner{at}icr.ac.uk

↵* Present address: Translational Science, Oncology iMed, AstraZeneca, Cambridge CB4 0WG, UK.

See allHide authors and affiliations

Science Translational Medicine 11 Nov 2015:
Vol. 7, Issue 313, pp. 313ra182
DOI: 10.1126/scitranslmed.aac7551

Gaia Schiavon

The Breast Cancer Now Research Centre, The Institute of Cancer Research, London SW3 6JB, UK.Breast Unit, Royal Marsden Hospital, Fulham Road, London SW3 6JJ, UK.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Sarah Hrebien

The Breast Cancer Now Research Centre, The Institute of Cancer Research, London SW3 6JB, UK.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Isaac Garcia-Murillas

The Breast Cancer Now Research Centre, The Institute of Cancer Research, London SW3 6JB, UK.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Rosalind J. Cutts

The Breast Cancer Now Research Centre, The Institute of Cancer Research, London SW3 6JB, UK.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Alex Pearson

The Breast Cancer Now Research Centre, The Institute of Cancer Research, London SW3 6JB, UK.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Noelia Tarazona

The Breast Cancer Now Research Centre, The Institute of Cancer Research, London SW3 6JB, UK.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Kerry Fenwick

The Breast Cancer Now Research Centre, The Institute of Cancer Research, London SW3 6JB, UK.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Iwanka Kozarewa

The Breast Cancer Now Research Centre, The Institute of Cancer Research, London SW3 6JB, UK.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Elena Lopez-Knowles

The Breast Cancer Now Research Centre, The Institute of Cancer Research, London SW3 6JB, UK.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Ricardo Ribas

The Breast Cancer Now Research Centre, The Institute of Cancer Research, London SW3 6JB, UK.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Ashutosh Nerurkar

Breast Unit, Royal Marsden Hospital, Fulham Road, London SW3 6JJ, UK.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Peter Osin

Breast Unit, Royal Marsden Hospital, Fulham Road, London SW3 6JJ, UK.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Sarat Chandarlapaty

Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Lesley-Ann Martin

The Breast Cancer Now Research Centre, The Institute of Cancer Research, London SW3 6JB, UK.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Mitch Dowsett

The Breast Cancer Now Research Centre, The Institute of Cancer Research, London SW3 6JB, UK.Breast Unit, Royal Marsden Hospital, Fulham Road, London SW3 6JJ, UK.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Ian E. Smith

The Breast Cancer Now Research Centre, The Institute of Cancer Research, London SW3 6JB, UK.Breast Unit, Royal Marsden Hospital, Fulham Road, London SW3 6JJ, UK.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Nicholas C. Turner

The Breast Cancer Now Research Centre, The Institute of Cancer Research, London SW3 6JB, UK.Breast Unit, Royal Marsden Hospital, Fulham Road, London SW3 6JJ, UK.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
For correspondence: nicholas.turner@icr.ac.uk

Article
Figures & Data
Info & Metrics
eLetters
PDF

eLetters is an online forum for ongoing peer review. Submission of eLetters are open to all. Please read our Terms of Service before submitting your own eLetter.

Submit a Response to This Article

Compose eLetter

Title

Contents

More information about text formats

Plain text

Plain text
No HTML tags allowed.
Web page addresses and e-mail addresses turn into links automatically.
Lines and paragraphs break automatically.

Author Information

Contributors
First name and middle name First or given name, e.g. 'Peter'. Last Name Your last, or family, name, e.g. 'MacMoody'. Email Your email address, e.g. higgs-boson@gmail.com Role / Occupation Your role and/or occupation, e.g. 'Orthopedic Surgeon'. Affiliation Your organization or institution (if applicable), e.g. 'Royal Free Hospital'.

Statement of Competing Interests

Competing interests?

Yes

Please describe the competing interests

CAPTCHA

This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.

What code is in the image? Enter the characters shown in the image.

Vertical Tabs

No eLetters have been published for this article.

View Full Text

Analysis of ESR1 mutation in circulating tumor DNA demonstrates evolution during therapy for metastatic breast cancer

Plain text

Vertical Tabs

Science Translational Medicine

Article Tools